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Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

BACKGROUND: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture. Here, we demonstrate that CRC liver metastases o...

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Detalles Bibliográficos
Autores principales:	Buzzelli, Jon N., Ouaret, Djamila, Brown, Graham, Allen, Philip D., Muschel, Ruth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842239/ https://www.ncbi.nlm.nih.gov/pubmed/29414601 http://dx.doi.org/10.1016/j.scr.2018.01.016

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