Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons

Hepatic insulin resistance and increased gluconeogenesis are known therapeutic targets of metformin, but the role of hepatic glycogen in the pathogenesis of diabetes is less clear. Mouse model of neuropeptide Y (NPY) overexpression in noradrenergic neurons (OE‐NPY(D) (βH)) with a phenotype of late o...

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Detalles Bibliográficos
Autores principales: Ailanen, Liisa, Bezborodkina, Natalia N., Virtanen, Laura, Ruohonen, Suvi T., Malova, Anastasia V., Okovityi, Sergey V., Chistyakova, Elizaveta Y., Savontaus, Eriika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842371/
https://www.ncbi.nlm.nih.gov/pubmed/29541475
http://dx.doi.org/10.1002/prp2.389

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