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Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842489/ https://www.ncbi.nlm.nih.gov/pubmed/29606972 http://dx.doi.org/10.4103/1735-5362.223803 |
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author | Nematbakhsh, Mehdi Mansouri, Azam |
author_facet | Nematbakhsh, Mehdi Mansouri, Azam |
author_sort | Nematbakhsh, Mehdi |
collection | PubMed |
description | Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors. |
format | Online Article Text |
id | pubmed-5842489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58424892018-04-01 Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor Nematbakhsh, Mehdi Mansouri, Azam Res Pharm Sci Short Communication Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors. Medknow Publications & Media Pvt Ltd 2018-04 /pmc/articles/PMC5842489/ /pubmed/29606972 http://dx.doi.org/10.4103/1735-5362.223803 Text en Copyright: © 2018 Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Short Communication Nematbakhsh, Mehdi Mansouri, Azam Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title_full | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title_fullStr | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title_full_unstemmed | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title_short | Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor |
title_sort | renal vascular response to angiotensin 1-7 in rats: the role of mas receptor |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842489/ https://www.ncbi.nlm.nih.gov/pubmed/29606972 http://dx.doi.org/10.4103/1735-5362.223803 |
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