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Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor

Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7...

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Autores principales: Nematbakhsh, Mehdi, Mansouri, Azam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842489/
https://www.ncbi.nlm.nih.gov/pubmed/29606972
http://dx.doi.org/10.4103/1735-5362.223803
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author Nematbakhsh, Mehdi
Mansouri, Azam
author_facet Nematbakhsh, Mehdi
Mansouri, Azam
author_sort Nematbakhsh, Mehdi
collection PubMed
description Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors.
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spelling pubmed-58424892018-04-01 Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor Nematbakhsh, Mehdi Mansouri, Azam Res Pharm Sci Short Communication Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors. Medknow Publications & Media Pvt Ltd 2018-04 /pmc/articles/PMC5842489/ /pubmed/29606972 http://dx.doi.org/10.4103/1735-5362.223803 Text en Copyright: © 2018 Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Short Communication
Nematbakhsh, Mehdi
Mansouri, Azam
Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title_full Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title_fullStr Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title_full_unstemmed Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title_short Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
title_sort renal vascular response to angiotensin 1-7 in rats: the role of mas receptor
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842489/
https://www.ncbi.nlm.nih.gov/pubmed/29606972
http://dx.doi.org/10.4103/1735-5362.223803
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