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Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia

BACKGROUND: Degeneration of cone photoreceptors leads to loss of vision in patients suffering from age-related macular degeneration (AMD) and other cone dystrophies. Evidence, such as choroidal ischemia and decreased choroidal blood flow, implicates reduced tissue oxygenation in AMD pathology and su...

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Detalles Bibliográficos
Autores principales:	Barben, Maya, Schori, Christian, Samardzija, Marijana, Grimm, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842520/ https://www.ncbi.nlm.nih.gov/pubmed/29514656 http://dx.doi.org/10.1186/s13024-018-0243-y

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