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Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

BACKGROUND: Using high-dimensional penalized regression we studied genome-wide DNA-methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral density (BMD). The women showed BMD varying from severely osteoporotic to normal. Global gene expression data from the same ind...

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Detalles Bibliográficos
Autores principales:	Lien, Tonje G., Borgan, Ørnulf, Reppe, Sjur, Gautvik, Kaare, Glad, Ingrid Kristine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842543/ https://www.ncbi.nlm.nih.gov/pubmed/29514638 http://dx.doi.org/10.1186/s12920-018-0341-2

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