Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients

Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The presen...

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Autores principales: Guedes, Cizelene do Carmo Faleiros Veloso, de Freitas Filho, Silas Antonio Juvencio, de Faria, Paulo Rogério, Loyola, Adriano Mota, Sabino-Silva, Robinson, Cardoso, Sérgio Vitorino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842683/
https://www.ncbi.nlm.nih.gov/pubmed/29681940
http://dx.doi.org/10.1155/2018/4579279
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author Guedes, Cizelene do Carmo Faleiros Veloso
de Freitas Filho, Silas Antonio Juvencio
de Faria, Paulo Rogério
Loyola, Adriano Mota
Sabino-Silva, Robinson
Cardoso, Sérgio Vitorino
author_facet Guedes, Cizelene do Carmo Faleiros Veloso
de Freitas Filho, Silas Antonio Juvencio
de Faria, Paulo Rogério
Loyola, Adriano Mota
Sabino-Silva, Robinson
Cardoso, Sérgio Vitorino
author_sort Guedes, Cizelene do Carmo Faleiros Veloso
collection PubMed
description Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences. Fifty-eight patients undergoing radiotherapy were randomized into two groups, distinguished according to the energy delivered by laser irradiation, namely, 0.25 J and 1.0 J. The groups were compared according to frequency, severity, or duration of OM, as well as the frequency of tumoral recurrences. OM was significantly less frequent in patients receiving 1.0 J of energy, but the groups did not differ regarding severity or duration of OM. Tumoral recurrence also did not vary significantly between the groups. Photobiomodulation with a higher dose of energy (1.0 J versus 0.25 J) is associated with better control of radiotherapy-induced OM and does not significantly increase the risk of neoplastic recurrence.
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spelling pubmed-58426832018-04-21 Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients Guedes, Cizelene do Carmo Faleiros Veloso de Freitas Filho, Silas Antonio Juvencio de Faria, Paulo Rogério Loyola, Adriano Mota Sabino-Silva, Robinson Cardoso, Sérgio Vitorino Int J Dent Research Article Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences. Fifty-eight patients undergoing radiotherapy were randomized into two groups, distinguished according to the energy delivered by laser irradiation, namely, 0.25 J and 1.0 J. The groups were compared according to frequency, severity, or duration of OM, as well as the frequency of tumoral recurrences. OM was significantly less frequent in patients receiving 1.0 J of energy, but the groups did not differ regarding severity or duration of OM. Tumoral recurrence also did not vary significantly between the groups. Photobiomodulation with a higher dose of energy (1.0 J versus 0.25 J) is associated with better control of radiotherapy-induced OM and does not significantly increase the risk of neoplastic recurrence. Hindawi 2018-02-22 /pmc/articles/PMC5842683/ /pubmed/29681940 http://dx.doi.org/10.1155/2018/4579279 Text en Copyright © 2018 Cizelene do Carmo Faleiros Veloso Guedes et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guedes, Cizelene do Carmo Faleiros Veloso
de Freitas Filho, Silas Antonio Juvencio
de Faria, Paulo Rogério
Loyola, Adriano Mota
Sabino-Silva, Robinson
Cardoso, Sérgio Vitorino
Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title_full Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title_fullStr Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title_full_unstemmed Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title_short Variation of Energy in Photobiomodulation for the Control of Radiotherapy-Induced Oral Mucositis: A Clinical Study in Head and Neck Cancer Patients
title_sort variation of energy in photobiomodulation for the control of radiotherapy-induced oral mucositis: a clinical study in head and neck cancer patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842683/
https://www.ncbi.nlm.nih.gov/pubmed/29681940
http://dx.doi.org/10.1155/2018/4579279
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