In vivo characterization of the physicochemical properties of TLR agonist delivery that enhance vaccine immunogenicity

The efficacy of vaccine adjuvants such as Toll-like receptor agonists (TLRa) can be improved through formulation and delivery approaches. Here, we attached small molecule TLR-7/8a to polymer scaffolds (polymer-TLR-7/8a) and evaluated how varying physicochemical properties of the TLR-7/8a and polymer...

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Detalles Bibliográficos
Autores principales: Lynn, Geoffrey M., Laga, Richard, Darrah, Patricia A., Ishizuka, Andrew S., Balaci, Alexandra J., Dulcey, Andrés E., Pechar, Michal, Pola, Robert, Gerner, Michael Y., Yamamoto, Ayako, Buechler, Connor R., Quinn, Kylie M., Smelkinson, Margery G., Vanek, Ondrej, Cawood, Ryan, Hills, Thomas, Vasalatiy, Olga, Kastenmuller, Kathrin, Francica, Joseph R., Stutts, Lalisa, Tom, Janine K., Ryu, Keun Ah, Esser-Kahn, Aaron P., Etrych, Tomas, Fisher, Kerry D., Seymour, Leonard W., Seder, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842712/
https://www.ncbi.nlm.nih.gov/pubmed/26501954
http://dx.doi.org/10.1038/nbt.3371

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