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Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition

The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment fo...

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Autores principales: Díez-Cirarda, María, Strafella, Antonio P., Kim, Jinhee, Peña, Javier, Ojeda, Natalia, Cabrera-Zubizarreta, Alberto, Ibarretxe-Bilbao, Naroa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842729/
https://www.ncbi.nlm.nih.gov/pubmed/29527489
http://dx.doi.org/10.1016/j.nicl.2017.12.013
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author Díez-Cirarda, María
Strafella, Antonio P.
Kim, Jinhee
Peña, Javier
Ojeda, Natalia
Cabrera-Zubizarreta, Alberto
Ibarretxe-Bilbao, Naroa
author_facet Díez-Cirarda, María
Strafella, Antonio P.
Kim, Jinhee
Peña, Javier
Ojeda, Natalia
Cabrera-Zubizarreta, Alberto
Ibarretxe-Bilbao, Naroa
author_sort Díez-Cirarda, María
collection PubMed
description The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB). Dynamic FC analysis was performed using the GIFT toolbox. FC differences between groups in each FC state were analysed with the network-based statistic (NBS) approach. Finally, a graph-theoretical analysis for local/global parameters was performed. The whole sample showed 2 dynamic FC states during the rs-fMRI. PD-MCI patients showed decreased mean dwell time in the hypo-connectivity state (p = 0.030) and showed increased number of state transitions (p = 0.007) compared with the HC. In addition, in the hypo-connectivity state, PD-MCI patients showed reduced inter-network FC between the SM-CC, SM-VI, SM-AUD, CC-VI and SC-DMN compared with the HC (p < 0.05-FDR). These FC alterations in PD-MCI were accompanied by graph-topological alterations in nodes located in the SM network (p < 0.001). In contrast, no differences were found between the PD-NC and HC. Findings suggest the presence of dynamic functional brain deteriorations in PD-MCI that are not present in PD-NC, showing the PD-MCI group dynamic FC dysfunctions, reduced FC mostly between SM-CC networks and graph-topological deteriorations in the SM network. A dynamic FC approach could be helpful to understand cognitive deterioration in PD.
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spelling pubmed-58427292018-03-09 Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition Díez-Cirarda, María Strafella, Antonio P. Kim, Jinhee Peña, Javier Ojeda, Natalia Cabrera-Zubizarreta, Alberto Ibarretxe-Bilbao, Naroa Neuroimage Clin Regular Article The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB). Dynamic FC analysis was performed using the GIFT toolbox. FC differences between groups in each FC state were analysed with the network-based statistic (NBS) approach. Finally, a graph-theoretical analysis for local/global parameters was performed. The whole sample showed 2 dynamic FC states during the rs-fMRI. PD-MCI patients showed decreased mean dwell time in the hypo-connectivity state (p = 0.030) and showed increased number of state transitions (p = 0.007) compared with the HC. In addition, in the hypo-connectivity state, PD-MCI patients showed reduced inter-network FC between the SM-CC, SM-VI, SM-AUD, CC-VI and SC-DMN compared with the HC (p < 0.05-FDR). These FC alterations in PD-MCI were accompanied by graph-topological alterations in nodes located in the SM network (p < 0.001). In contrast, no differences were found between the PD-NC and HC. Findings suggest the presence of dynamic functional brain deteriorations in PD-MCI that are not present in PD-NC, showing the PD-MCI group dynamic FC dysfunctions, reduced FC mostly between SM-CC networks and graph-topological deteriorations in the SM network. A dynamic FC approach could be helpful to understand cognitive deterioration in PD. Elsevier 2017-12-09 /pmc/articles/PMC5842729/ /pubmed/29527489 http://dx.doi.org/10.1016/j.nicl.2017.12.013 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Díez-Cirarda, María
Strafella, Antonio P.
Kim, Jinhee
Peña, Javier
Ojeda, Natalia
Cabrera-Zubizarreta, Alberto
Ibarretxe-Bilbao, Naroa
Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title_full Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title_fullStr Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title_full_unstemmed Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title_short Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
title_sort dynamic functional connectivity in parkinson's disease patients with mild cognitive impairment and normal cognition
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842729/
https://www.ncbi.nlm.nih.gov/pubmed/29527489
http://dx.doi.org/10.1016/j.nicl.2017.12.013
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