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Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery

OBJECTIVES/AIMS: The aim of this study was to investigate the microbial cultures collected in the years 2013–2014 at the craniomaxillofacial department and outpatient clinic to analyse optimisation of the treatment cost of the bacterial infections and present the results. DESIGN AND SETTING: We anal...

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Autores principales: Orzechowska-Wylęgała, Bogusława, Wylęgała, Adam, Buliński, Michał, Niedzielska, Iwona, Madej, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842825/
https://www.ncbi.nlm.nih.gov/pubmed/29607075
http://dx.doi.org/10.1038/bdjopen.2017.2
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author Orzechowska-Wylęgała, Bogusława
Wylęgała, Adam
Buliński, Michał
Niedzielska, Iwona
Madej, Andrzej
author_facet Orzechowska-Wylęgała, Bogusława
Wylęgała, Adam
Buliński, Michał
Niedzielska, Iwona
Madej, Andrzej
author_sort Orzechowska-Wylęgała, Bogusława
collection PubMed
description OBJECTIVES/AIMS: The aim of this study was to investigate the microbial cultures collected in the years 2013–2014 at the craniomaxillofacial department and outpatient clinic to analyse optimisation of the treatment cost of the bacterial infections and present the results. DESIGN AND SETTING: We analysed 485 cultures from 263 patients, of which 77.28% consisted of Gram-positive bacteria. On the basis of the antibiotic efficacy, antibiotic price and the cost of entire treatment during hospitalisation, the most useful antimicrobial agents for the most common pathogens were selected. RESULTS: The most frequently collected material was pus. The most common pathogens were found to be the Staphylococcus epidermidis (18%), Streptococcus mitis and Str. oralis (14%) and S. aureus (6.5%). DISCUSSION: The most frequently isolated bacteria in other studies were the Streptococcus strain. Other authors showed that ceftriaxone is the most cost efficient agent. The use of postoperative antibiotic prophylaxis remains controversial. CONCLUSION: The results of this study suggest that the most useful antibiotics for therapy, from the perspective of the cost minimisation, were gentamycin, trimethoprim with sulfamethoxazole and vancomycin.
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spelling pubmed-58428252018-03-30 Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery Orzechowska-Wylęgała, Bogusława Wylęgała, Adam Buliński, Michał Niedzielska, Iwona Madej, Andrzej BDJ Open Article OBJECTIVES/AIMS: The aim of this study was to investigate the microbial cultures collected in the years 2013–2014 at the craniomaxillofacial department and outpatient clinic to analyse optimisation of the treatment cost of the bacterial infections and present the results. DESIGN AND SETTING: We analysed 485 cultures from 263 patients, of which 77.28% consisted of Gram-positive bacteria. On the basis of the antibiotic efficacy, antibiotic price and the cost of entire treatment during hospitalisation, the most useful antimicrobial agents for the most common pathogens were selected. RESULTS: The most frequently collected material was pus. The most common pathogens were found to be the Staphylococcus epidermidis (18%), Streptococcus mitis and Str. oralis (14%) and S. aureus (6.5%). DISCUSSION: The most frequently isolated bacteria in other studies were the Streptococcus strain. Other authors showed that ceftriaxone is the most cost efficient agent. The use of postoperative antibiotic prophylaxis remains controversial. CONCLUSION: The results of this study suggest that the most useful antibiotics for therapy, from the perspective of the cost minimisation, were gentamycin, trimethoprim with sulfamethoxazole and vancomycin. Nature Publishing Group 2017-02-10 /pmc/articles/PMC5842825/ /pubmed/29607075 http://dx.doi.org/10.1038/bdjopen.2017.2 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Orzechowska-Wylęgała, Bogusława
Wylęgała, Adam
Buliński, Michał
Niedzielska, Iwona
Madej, Andrzej
Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title_full Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title_fullStr Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title_full_unstemmed Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title_short Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
title_sort pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842825/
https://www.ncbi.nlm.nih.gov/pubmed/29607075
http://dx.doi.org/10.1038/bdjopen.2017.2
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