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Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model

Circular RNAs (circRNAs), a novel kind of non-coding RNA, have received increasing attention for their involvement in pathogenesis of Alzheimer’s disease (AD); however, few studies have reported in the characterization and function of AD associated circRNAs. Here the expression profiles of circRNAs...

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Autores principales: Huang, Jin-Lan, Qin, Mei-Chun, Zhou, Yan, Xu, Zhe-Hao, Yang, Si-man, Zhang, Fan, Zhong, Jing, Liang, Ming-Kun, Chen, Ben, Zhang, Wen-Yan, Wu, Deng-Pan, Zhong, Zhen-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842852/
https://www.ncbi.nlm.nih.gov/pubmed/29448241
http://dx.doi.org/10.18632/aging.101387
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author Huang, Jin-Lan
Qin, Mei-Chun
Zhou, Yan
Xu, Zhe-Hao
Yang, Si-man
Zhang, Fan
Zhong, Jing
Liang, Ming-Kun
Chen, Ben
Zhang, Wen-Yan
Wu, Deng-Pan
Zhong, Zhen-Guo
author_facet Huang, Jin-Lan
Qin, Mei-Chun
Zhou, Yan
Xu, Zhe-Hao
Yang, Si-man
Zhang, Fan
Zhong, Jing
Liang, Ming-Kun
Chen, Ben
Zhang, Wen-Yan
Wu, Deng-Pan
Zhong, Zhen-Guo
author_sort Huang, Jin-Lan
collection PubMed
description Circular RNAs (circRNAs), a novel kind of non-coding RNA, have received increasing attention for their involvement in pathogenesis of Alzheimer’s disease (AD); however, few studies have reported in the characterization and function of AD associated circRNAs. Here the expression profiles of circRNAs in 5- and 10-month-old SAMP8 mice were identified using circRNA microarray and found that 85 dysregulated circRNAs were observed in 10-month-old SAMP8 versus control mice and 231 circRNAs exhibited differential expression in 10-month-old SAMP8 versus 5-month-old SAMP8. One most significantly dysregulated circRNA, mmu_circRNA_017963, was select for Gene Oncology (GO) and pathway analysis. The results showed that mmu_circRNA_017963 was strongly related with autophagosome assembly, exocytosis, apoptotic process, transport and RNA splicing and highly associated with synaptic vesicle cycle, spliceosome, glycosaminoglycan and SNARE interactions in vesicular transport pathways. Collectively, this study was the first to describe circRNAs expression in different ages of SAMP8 and will contribute to the understanding of the regulatory roles of circRNAs in AD pathogenesis and provide a valuable resource for the diagnosis and therapy of AD.
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spelling pubmed-58428522018-03-14 Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model Huang, Jin-Lan Qin, Mei-Chun Zhou, Yan Xu, Zhe-Hao Yang, Si-man Zhang, Fan Zhong, Jing Liang, Ming-Kun Chen, Ben Zhang, Wen-Yan Wu, Deng-Pan Zhong, Zhen-Guo Aging (Albany NY) Research Paper Circular RNAs (circRNAs), a novel kind of non-coding RNA, have received increasing attention for their involvement in pathogenesis of Alzheimer’s disease (AD); however, few studies have reported in the characterization and function of AD associated circRNAs. Here the expression profiles of circRNAs in 5- and 10-month-old SAMP8 mice were identified using circRNA microarray and found that 85 dysregulated circRNAs were observed in 10-month-old SAMP8 versus control mice and 231 circRNAs exhibited differential expression in 10-month-old SAMP8 versus 5-month-old SAMP8. One most significantly dysregulated circRNA, mmu_circRNA_017963, was select for Gene Oncology (GO) and pathway analysis. The results showed that mmu_circRNA_017963 was strongly related with autophagosome assembly, exocytosis, apoptotic process, transport and RNA splicing and highly associated with synaptic vesicle cycle, spliceosome, glycosaminoglycan and SNARE interactions in vesicular transport pathways. Collectively, this study was the first to describe circRNAs expression in different ages of SAMP8 and will contribute to the understanding of the regulatory roles of circRNAs in AD pathogenesis and provide a valuable resource for the diagnosis and therapy of AD. Impact Journals 2018-02-15 /pmc/articles/PMC5842852/ /pubmed/29448241 http://dx.doi.org/10.18632/aging.101387 Text en Copyright © 2018 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Huang, Jin-Lan
Qin, Mei-Chun
Zhou, Yan
Xu, Zhe-Hao
Yang, Si-man
Zhang, Fan
Zhong, Jing
Liang, Ming-Kun
Chen, Ben
Zhang, Wen-Yan
Wu, Deng-Pan
Zhong, Zhen-Guo
Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title_full Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title_fullStr Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title_full_unstemmed Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title_short Comprehensive analysis of differentially expressed profiles of Alzheimer’s disease associated circular RNAs in an Alzheimer’s disease mouse model
title_sort comprehensive analysis of differentially expressed profiles of alzheimer’s disease associated circular rnas in an alzheimer’s disease mouse model
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842852/
https://www.ncbi.nlm.nih.gov/pubmed/29448241
http://dx.doi.org/10.18632/aging.101387
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