Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls

Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the r...

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Autores principales: Liu, Di, Zheng, Yi, Wang, Meng, Deng, Yujiao, Lin, Shuai, Zhou, Linghui, Yang, Pengtao, Dai, Cong, Xu, Peng, Hao, Qian, Song, Dingli, Kang, Huafeng, Dai, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842853/
https://www.ncbi.nlm.nih.gov/pubmed/29466248
http://dx.doi.org/10.18632/aging.101388
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author Liu, Di
Zheng, Yi
Wang, Meng
Deng, Yujiao
Lin, Shuai
Zhou, Linghui
Yang, Pengtao
Dai, Cong
Xu, Peng
Hao, Qian
Song, Dingli
Kang, Huafeng
Dai, Zhijun
author_facet Liu, Di
Zheng, Yi
Wang, Meng
Deng, Yujiao
Lin, Shuai
Zhou, Linghui
Yang, Pengtao
Dai, Cong
Xu, Peng
Hao, Qian
Song, Dingli
Kang, Huafeng
Dai, Zhijun
author_sort Liu, Di
collection PubMed
description Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.
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spelling pubmed-58428532018-03-14 Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls Liu, Di Zheng, Yi Wang, Meng Deng, Yujiao Lin, Shuai Zhou, Linghui Yang, Pengtao Dai, Cong Xu, Peng Hao, Qian Song, Dingli Kang, Huafeng Dai, Zhijun Aging (Albany NY) Research Paper Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population. Impact Journals 2018-02-16 /pmc/articles/PMC5842853/ /pubmed/29466248 http://dx.doi.org/10.18632/aging.101388 Text en Copyright © 2018 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Liu, Di
Zheng, Yi
Wang, Meng
Deng, Yujiao
Lin, Shuai
Zhou, Linghui
Yang, Pengtao
Dai, Cong
Xu, Peng
Hao, Qian
Song, Dingli
Kang, Huafeng
Dai, Zhijun
Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title_full Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title_fullStr Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title_full_unstemmed Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title_short Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
title_sort four common polymorphisms of brip1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842853/
https://www.ncbi.nlm.nih.gov/pubmed/29466248
http://dx.doi.org/10.18632/aging.101388
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