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The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers

Antibody affinity maturation occurs in germinal centres (GC) where B cells cycle between the light zone (LZ) and the dark zone. In the LZ GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from T helper cells that promotes their rapid prolifer...

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Detalles Bibliográficos
Autores principales:	Monzón-Casanova, Elisa, Screen, Michael, Díaz-Muñoz, Manuel D., Coulson, Richard M. R., Bell, Sarah E., Lamers, Greta, Solimena, Michele, Smith, Christopher W.J., Turner, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842895/ https://www.ncbi.nlm.nih.gov/pubmed/29358707 http://dx.doi.org/10.1038/s41590-017-0035-5

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