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Plasma citrate concentration: a possible biomarker for glaucoma in children

OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study...

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Autores principales: Michalczuk, Marta, Tadeusz, Porowski, Urban, Beata, Anna, Wasilewska, Bakunowicz- Łazarczyk, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843004/
https://www.ncbi.nlm.nih.gov/pubmed/29637096
http://dx.doi.org/10.1136/bmjpo-2017-000023
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author Michalczuk, Marta
Tadeusz, Porowski
Urban, Beata
Anna, Wasilewska
Bakunowicz- Łazarczyk, Alina
author_facet Michalczuk, Marta
Tadeusz, Porowski
Urban, Beata
Anna, Wasilewska
Bakunowicz- Łazarczyk, Alina
author_sort Michalczuk, Marta
collection PubMed
description OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared. RESULTS: Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667). CONCLUSION: Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population.
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spelling pubmed-58430042018-04-10 Plasma citrate concentration: a possible biomarker for glaucoma in children Michalczuk, Marta Tadeusz, Porowski Urban, Beata Anna, Wasilewska Bakunowicz- Łazarczyk, Alina BMJ Paediatr Open Original Article OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared. RESULTS: Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667). CONCLUSION: Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population. BMJ Publishing Group 2017-07-03 /pmc/articles/PMC5843004/ /pubmed/29637096 http://dx.doi.org/10.1136/bmjpo-2017-000023 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Original Article
Michalczuk, Marta
Tadeusz, Porowski
Urban, Beata
Anna, Wasilewska
Bakunowicz- Łazarczyk, Alina
Plasma citrate concentration: a possible biomarker for glaucoma in children
title Plasma citrate concentration: a possible biomarker for glaucoma in children
title_full Plasma citrate concentration: a possible biomarker for glaucoma in children
title_fullStr Plasma citrate concentration: a possible biomarker for glaucoma in children
title_full_unstemmed Plasma citrate concentration: a possible biomarker for glaucoma in children
title_short Plasma citrate concentration: a possible biomarker for glaucoma in children
title_sort plasma citrate concentration: a possible biomarker for glaucoma in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843004/
https://www.ncbi.nlm.nih.gov/pubmed/29637096
http://dx.doi.org/10.1136/bmjpo-2017-000023
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