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Plasma citrate concentration: a possible biomarker for glaucoma in children
OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843004/ https://www.ncbi.nlm.nih.gov/pubmed/29637096 http://dx.doi.org/10.1136/bmjpo-2017-000023 |
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author | Michalczuk, Marta Tadeusz, Porowski Urban, Beata Anna, Wasilewska Bakunowicz- Łazarczyk, Alina |
author_facet | Michalczuk, Marta Tadeusz, Porowski Urban, Beata Anna, Wasilewska Bakunowicz- Łazarczyk, Alina |
author_sort | Michalczuk, Marta |
collection | PubMed |
description | OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared. RESULTS: Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667). CONCLUSION: Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population. |
format | Online Article Text |
id | pubmed-5843004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58430042018-04-10 Plasma citrate concentration: a possible biomarker for glaucoma in children Michalczuk, Marta Tadeusz, Porowski Urban, Beata Anna, Wasilewska Bakunowicz- Łazarczyk, Alina BMJ Paediatr Open Original Article OBJECTIVES: The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. PATIENTS: 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared. RESULTS: Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667). CONCLUSION: Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population. BMJ Publishing Group 2017-07-03 /pmc/articles/PMC5843004/ /pubmed/29637096 http://dx.doi.org/10.1136/bmjpo-2017-000023 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Original Article Michalczuk, Marta Tadeusz, Porowski Urban, Beata Anna, Wasilewska Bakunowicz- Łazarczyk, Alina Plasma citrate concentration: a possible biomarker for glaucoma in children |
title | Plasma citrate concentration: a possible biomarker for glaucoma in children |
title_full | Plasma citrate concentration: a possible biomarker for glaucoma in children |
title_fullStr | Plasma citrate concentration: a possible biomarker for glaucoma in children |
title_full_unstemmed | Plasma citrate concentration: a possible biomarker for glaucoma in children |
title_short | Plasma citrate concentration: a possible biomarker for glaucoma in children |
title_sort | plasma citrate concentration: a possible biomarker for glaucoma in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843004/ https://www.ncbi.nlm.nih.gov/pubmed/29637096 http://dx.doi.org/10.1136/bmjpo-2017-000023 |
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