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A case of emmonsiosis in an HIV-infected child

Opportunistic fungal infections can cause significant morbidity and mortality in immunocompromised patients. We describe a paediatric case of an unusual disseminated fungal infection. A three-year-old HIV-infected child with severe immunosuppression (CD4+ T-cell count 12 × 10(6)/L) was admitted to h...

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Autores principales: Lochan, Harsha, Naicker, Preneshni, Maphanga, Tsidiso, Ryan, Anthea, Pillay, Komala, Govender, Nelesh P., Eley, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS OpenJournals 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843156/
https://www.ncbi.nlm.nih.gov/pubmed/29568581
http://dx.doi.org/10.4102/sajhivmed.v16i1.352
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author Lochan, Harsha
Naicker, Preneshni
Maphanga, Tsidiso
Ryan, Anthea
Pillay, Komala
Govender, Nelesh P.
Eley, Brian
author_facet Lochan, Harsha
Naicker, Preneshni
Maphanga, Tsidiso
Ryan, Anthea
Pillay, Komala
Govender, Nelesh P.
Eley, Brian
author_sort Lochan, Harsha
collection PubMed
description Opportunistic fungal infections can cause significant morbidity and mortality in immunocompromised patients. We describe a paediatric case of an unusual disseminated fungal infection. A three-year-old HIV-infected child with severe immunosuppression (CD4+ T-cell count 12 × 10(6)/L) was admitted to hospital with pneumonia, gastroenteritis and herpes gingivostomatitis. Despite antibacterial and antiviral therapy, he experienced high fevers and developed an erythematous maculopapular rash and abdominal tenderness. The child's condition progressively worsened during the admission. A thermally dimorphic fungus was cultured from bone marrow and identified as an Emmonsia species on DNA sequencing. The patient made a good recovery on amphotericin B deoxycholate and antiretroviral therapy. Itraconazole was continued for a minimum of 12 months, allowing for immune reconstitution to occur. This case is the first documented description of disseminated disease caused by a novel Emmonsia species in an HIV-infected child in South Africa.
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spelling pubmed-58431562018-03-22 A case of emmonsiosis in an HIV-infected child Lochan, Harsha Naicker, Preneshni Maphanga, Tsidiso Ryan, Anthea Pillay, Komala Govender, Nelesh P. Eley, Brian South Afr J HIV Med Case Report Opportunistic fungal infections can cause significant morbidity and mortality in immunocompromised patients. We describe a paediatric case of an unusual disseminated fungal infection. A three-year-old HIV-infected child with severe immunosuppression (CD4+ T-cell count 12 × 10(6)/L) was admitted to hospital with pneumonia, gastroenteritis and herpes gingivostomatitis. Despite antibacterial and antiviral therapy, he experienced high fevers and developed an erythematous maculopapular rash and abdominal tenderness. The child's condition progressively worsened during the admission. A thermally dimorphic fungus was cultured from bone marrow and identified as an Emmonsia species on DNA sequencing. The patient made a good recovery on amphotericin B deoxycholate and antiretroviral therapy. Itraconazole was continued for a minimum of 12 months, allowing for immune reconstitution to occur. This case is the first documented description of disseminated disease caused by a novel Emmonsia species in an HIV-infected child in South Africa. AOSIS OpenJournals 2015-06-11 /pmc/articles/PMC5843156/ /pubmed/29568581 http://dx.doi.org/10.4102/sajhivmed.v16i1.352 Text en © 2015. The Author(s) http://creativecommons.org/licenses/by/2.0/ Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.
spellingShingle Case Report
Lochan, Harsha
Naicker, Preneshni
Maphanga, Tsidiso
Ryan, Anthea
Pillay, Komala
Govender, Nelesh P.
Eley, Brian
A case of emmonsiosis in an HIV-infected child
title A case of emmonsiosis in an HIV-infected child
title_full A case of emmonsiosis in an HIV-infected child
title_fullStr A case of emmonsiosis in an HIV-infected child
title_full_unstemmed A case of emmonsiosis in an HIV-infected child
title_short A case of emmonsiosis in an HIV-infected child
title_sort case of emmonsiosis in an hiv-infected child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843156/
https://www.ncbi.nlm.nih.gov/pubmed/29568581
http://dx.doi.org/10.4102/sajhivmed.v16i1.352
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