The end of the line? A case of drug resistance to third-line antiretroviral therapy

HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment...

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Detalles Bibliográficos
Autores principales: Rossouw, Theresa M., Hitchcock, Sonia, Botes, Mariëtte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2016
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843205/
https://www.ncbi.nlm.nih.gov/pubmed/29568612
http://dx.doi.org/10.4102/sajhivmed.v17i1.454
Descripción
Sumario:HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus.

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