The end of the line? A case of drug resistance to third-line antiretroviral therapy

HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment...

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Detalles Bibliográficos
Autores principales: Rossouw, Theresa M., Hitchcock, Sonia, Botes, Mariëtte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2016
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843205/
https://www.ncbi.nlm.nih.gov/pubmed/29568612
http://dx.doi.org/10.4102/sajhivmed.v17i1.454
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author Rossouw, Theresa M.
Hitchcock, Sonia
Botes, Mariëtte
author_facet Rossouw, Theresa M.
Hitchcock, Sonia
Botes, Mariëtte
author_sort Rossouw, Theresa M.
collection PubMed
description HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus.
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spelling pubmed-58432052018-03-22 The end of the line? A case of drug resistance to third-line antiretroviral therapy Rossouw, Theresa M. Hitchcock, Sonia Botes, Mariëtte South Afr J HIV Med Case Reports HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa. This case illustrates the dilemma of treatment in the context of inadequate adherence and poor psychosocial support and highlights the potential risk of transmission of multidrug-resistant virus. AOSIS 2016-05-31 /pmc/articles/PMC5843205/ /pubmed/29568612 http://dx.doi.org/10.4102/sajhivmed.v17i1.454 Text en © 2016. The Authors http://creativecommons.org/licenses/by/2.0/ Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Case Reports
Rossouw, Theresa M.
Hitchcock, Sonia
Botes, Mariëtte
The end of the line? A case of drug resistance to third-line antiretroviral therapy
title The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_full The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_fullStr The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_full_unstemmed The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_short The end of the line? A case of drug resistance to third-line antiretroviral therapy
title_sort end of the line? a case of drug resistance to third-line antiretroviral therapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843205/
https://www.ncbi.nlm.nih.gov/pubmed/29568612
http://dx.doi.org/10.4102/sajhivmed.v17i1.454
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