BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression. Pharmacological inhibition of BRD4 by BET inhibitors (BETi) has indicated antitumor activity against multiple cancer types. We show that BRD4 is ess...

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Detalles Bibliográficos
Autores principales: Li, Xiangyi, Baek, GuemHee, Ramanand, Susmita G., Sharp, Adam, Gao, Yunpeng, Yuan, Wei, Welti, Jon, Rodrigues, Daniel N., Dolling, David, Figueiredo, Ines, Sumanasuriya, Semini, Crespo, Mateus, Aslam, Adam, Li, Rui, Yin, Yi, Mukherjee, Bipasha, Kanchwala, Mohammed, Hughes, Ashley M., Halsey, Wendy S., Chiang, Cheng-Ming, Xing, Chao, Raj, Ganesh V., Burma, Sandeep, de Bono, Johann, Mani, Ram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843368/
https://www.ncbi.nlm.nih.gov/pubmed/29346775
http://dx.doi.org/10.1016/j.celrep.2017.12.078

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