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CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation

Additional sex combs-like 1 (ASXL1) is a well-known tumor suppressor gene and epigenetic modifier. ASXL1 mutations are frequent in myeloid malignances; these mutations are risk factors for the development of myelodysplasia and also appear as small clones during normal aging. ASXL1 appears to act as...

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Detalles Bibliográficos
Autores principales:	Wu, Zhi-Jie, Zhao, Xin, Banaszak, Lauren G., Gutierrez-Rodrigues, Fernanda, Keyvanfar, Keyvan, Gao, Shou-Guo, Raffo, Diego Quinones, Kajigaya, Sachiko, Young, Neal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843401/ https://www.ncbi.nlm.nih.gov/pubmed/29532865 http://dx.doi.org/10.3892/ijo.2018.4290

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