The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in the immunoglobulin (Ig) switch regions. Here we show the role of Usp22, the SAGA complex deubiquitinase that removes ubiquitin from H2B-K120, i...

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Detalles Bibliográficos
Autores principales: Li, Conglei, Irrazabal, Thergiory, So, Clare C., Berru, Maribel, Du, Likun, Lam, Evelyn, Ling, Alexanda K., Gommerman, Jennifer L., Pan-Hammarström, Qiang, Martin, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843634/
https://www.ncbi.nlm.nih.gov/pubmed/29520062
http://dx.doi.org/10.1038/s41467-018-03455-x

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