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A proteomic landscape of diffuse-type gastric cancer
The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene products and mutation information of 274 cancer driver genes covering paired tumor and nearby...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843664/ https://www.ncbi.nlm.nih.gov/pubmed/29520031 http://dx.doi.org/10.1038/s41467-018-03121-2 |
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| author | Ge, Sai Xia, Xia Ding, Chen Zhen, Bei Zhou, Quan Feng, Jinwen Yuan, Jiajia Chen, Rui Li, Yumei Ge, Zhongqi Ji, Jiafu Zhang, Lianhai Wang, Jiayuan Li, Zhongwu Lai, Yumei Hu, Ying Li, Yanyan Li, Yilin Gao, Jing Chen, Lin Xu, Jianming Zhang, Chunchao Jung, Sung Yun Choi, Jong Min Jain, Antrix Liu, Mingwei Song, Lei Liu, Wanlin Guo, Gaigai Gong, Tongqing Huang, Yin Qiu, Yang Huang, Wenwen Shi, Tieliu Zhu, Weimin Wang, Yi He, Fuchu Shen, Lin Qin, Jun |
| author_facet | Ge, Sai Xia, Xia Ding, Chen Zhen, Bei Zhou, Quan Feng, Jinwen Yuan, Jiajia Chen, Rui Li, Yumei Ge, Zhongqi Ji, Jiafu Zhang, Lianhai Wang, Jiayuan Li, Zhongwu Lai, Yumei Hu, Ying Li, Yanyan Li, Yilin Gao, Jing Chen, Lin Xu, Jianming Zhang, Chunchao Jung, Sung Yun Choi, Jong Min Jain, Antrix Liu, Mingwei Song, Lei Liu, Wanlin Guo, Gaigai Gong, Tongqing Huang, Yin Qiu, Yang Huang, Wenwen Shi, Tieliu Zhu, Weimin Wang, Yi He, Fuchu Shen, Lin Qin, Jun |
| author_sort | Ge, Sai |
| collection | PubMed |
| description | The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene products and mutation information of 274 cancer driver genes covering paired tumor and nearby tissue. DGC can be classified into three subtypes (PX1–3) based on the altered proteome alone. PX1 and PX2 exhibit dysregulation in the cell cycle and PX2 features an additional EMT process; PX3 is enriched in immune response proteins, has the worst survival, and is insensitive to chemotherapy. Data analysis revealed four major vulnerabilities in DGC that may be targeted for treatment, and allowed the nomination of potential immunotherapy targets for DGC patients, particularly for those in PX3. This dataset provides a rich resource for information and knowledge mining toward altered signaling pathways in DGC and demonstrates the benefit of proteomic analysis in cancer molecular subtyping. |
| format | Online Article Text |
| id | pubmed-5843664 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58436642018-03-12 A proteomic landscape of diffuse-type gastric cancer Ge, Sai Xia, Xia Ding, Chen Zhen, Bei Zhou, Quan Feng, Jinwen Yuan, Jiajia Chen, Rui Li, Yumei Ge, Zhongqi Ji, Jiafu Zhang, Lianhai Wang, Jiayuan Li, Zhongwu Lai, Yumei Hu, Ying Li, Yanyan Li, Yilin Gao, Jing Chen, Lin Xu, Jianming Zhang, Chunchao Jung, Sung Yun Choi, Jong Min Jain, Antrix Liu, Mingwei Song, Lei Liu, Wanlin Guo, Gaigai Gong, Tongqing Huang, Yin Qiu, Yang Huang, Wenwen Shi, Tieliu Zhu, Weimin Wang, Yi He, Fuchu Shen, Lin Qin, Jun Nat Commun Article The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene products and mutation information of 274 cancer driver genes covering paired tumor and nearby tissue. DGC can be classified into three subtypes (PX1–3) based on the altered proteome alone. PX1 and PX2 exhibit dysregulation in the cell cycle and PX2 features an additional EMT process; PX3 is enriched in immune response proteins, has the worst survival, and is insensitive to chemotherapy. Data analysis revealed four major vulnerabilities in DGC that may be targeted for treatment, and allowed the nomination of potential immunotherapy targets for DGC patients, particularly for those in PX3. This dataset provides a rich resource for information and knowledge mining toward altered signaling pathways in DGC and demonstrates the benefit of proteomic analysis in cancer molecular subtyping. Nature Publishing Group UK 2018-03-08 /pmc/articles/PMC5843664/ /pubmed/29520031 http://dx.doi.org/10.1038/s41467-018-03121-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Ge, Sai Xia, Xia Ding, Chen Zhen, Bei Zhou, Quan Feng, Jinwen Yuan, Jiajia Chen, Rui Li, Yumei Ge, Zhongqi Ji, Jiafu Zhang, Lianhai Wang, Jiayuan Li, Zhongwu Lai, Yumei Hu, Ying Li, Yanyan Li, Yilin Gao, Jing Chen, Lin Xu, Jianming Zhang, Chunchao Jung, Sung Yun Choi, Jong Min Jain, Antrix Liu, Mingwei Song, Lei Liu, Wanlin Guo, Gaigai Gong, Tongqing Huang, Yin Qiu, Yang Huang, Wenwen Shi, Tieliu Zhu, Weimin Wang, Yi He, Fuchu Shen, Lin Qin, Jun A proteomic landscape of diffuse-type gastric cancer |
| title | A proteomic landscape of diffuse-type gastric cancer |
| title_full | A proteomic landscape of diffuse-type gastric cancer |
| title_fullStr | A proteomic landscape of diffuse-type gastric cancer |
| title_full_unstemmed | A proteomic landscape of diffuse-type gastric cancer |
| title_short | A proteomic landscape of diffuse-type gastric cancer |
| title_sort | proteomic landscape of diffuse-type gastric cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843664/ https://www.ncbi.nlm.nih.gov/pubmed/29520031 http://dx.doi.org/10.1038/s41467-018-03121-2 |
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