The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells

OBJECTIVE: N6-isopentenyladenosine (iPA) is an intermediate of the mevalonate pathway that exhibits various anti-cancer effects. However, studies on its anti-inflammatory activity are scarce and underlying molecular mechanisms are unknown. Therefore, we aimed to investigate the ability of iPA to exe...

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Detalles Bibliográficos
Autores principales: Santoro, Antonietta, Ciaglia, Elena, Nicolin, Vanessa, Pescatore, Alessandra, Prota, Lucia, Capunzo, Mario, Ursini, Matilde V., Nori, Stefania L., Bifulco, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843674/
https://www.ncbi.nlm.nih.gov/pubmed/29230506
http://dx.doi.org/10.1007/s00011-017-1123-6

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