Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission

BACKGROUND: Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [(18)F]JNJ42259152 PET to measure changes in PDE10A availability,...

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Detalles Bibliográficos
Autores principales: Ooms, Maarten, Celen, Sofie, De Hoogt, Ronald, Lenaerts, Ilse, Liebregts, Johnny, Vanhoof, Greet, Langlois, Xavier, Postnov, Andrey, Koole, Michel, Verbruggen, Alfons, Van Laere, Koen, Bormans, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843803/
https://www.ncbi.nlm.nih.gov/pubmed/29564380
http://dx.doi.org/10.1186/s41181-016-0005-5

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