Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics

(149)Tb represents a powerful alternative to currently used α-emitters: the relatively short half-life (T(1/2) = 4.1 h), low α-energy (3.97 MeV, I(α) = 16.7 %), absence of α-emitting daughters and stable coordination via DOTA are favorable features for potential clinical application. In this letter,...

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Autores principales: Müller, Cristina, Vermeulen, Christiaan, Köster, Ulli, Johnston, Karl, Türler, Andreas, Schibli, Roger, van der Meulen, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843804/
https://www.ncbi.nlm.nih.gov/pubmed/29564382
http://dx.doi.org/10.1186/s41181-016-0008-2
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author Müller, Cristina
Vermeulen, Christiaan
Köster, Ulli
Johnston, Karl
Türler, Andreas
Schibli, Roger
van der Meulen, Nicholas P.
author_facet Müller, Cristina
Vermeulen, Christiaan
Köster, Ulli
Johnston, Karl
Türler, Andreas
Schibli, Roger
van der Meulen, Nicholas P.
author_sort Müller, Cristina
collection PubMed
description (149)Tb represents a powerful alternative to currently used α-emitters: the relatively short half-life (T(1/2) = 4.1 h), low α-energy (3.97 MeV, I(α) = 16.7 %), absence of α-emitting daughters and stable coordination via DOTA are favorable features for potential clinical application. In this letter, we wish to highlight the unique characteristics of (149)Tb for PET imaging, based on its positron emission (E(β+mean) = 730 keV, I(β+) = 7.1 %) in addition to it’s a therapeutic value. To this end, a preclinical study with a tumor-bearing mouse is presented. The perspective of alpha-PET makes (149)Tb highly appealing for radiotheragnostic applications in future clinical trials.
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spelling pubmed-58438042018-03-19 Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics Müller, Cristina Vermeulen, Christiaan Köster, Ulli Johnston, Karl Türler, Andreas Schibli, Roger van der Meulen, Nicholas P. EJNMMI Radiopharm Chem Letter to the Editor (149)Tb represents a powerful alternative to currently used α-emitters: the relatively short half-life (T(1/2) = 4.1 h), low α-energy (3.97 MeV, I(α) = 16.7 %), absence of α-emitting daughters and stable coordination via DOTA are favorable features for potential clinical application. In this letter, we wish to highlight the unique characteristics of (149)Tb for PET imaging, based on its positron emission (E(β+mean) = 730 keV, I(β+) = 7.1 %) in addition to it’s a therapeutic value. To this end, a preclinical study with a tumor-bearing mouse is presented. The perspective of alpha-PET makes (149)Tb highly appealing for radiotheragnostic applications in future clinical trials. Springer International Publishing 2016-03-28 /pmc/articles/PMC5843804/ /pubmed/29564382 http://dx.doi.org/10.1186/s41181-016-0008-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Letter to the Editor
Müller, Cristina
Vermeulen, Christiaan
Köster, Ulli
Johnston, Karl
Türler, Andreas
Schibli, Roger
van der Meulen, Nicholas P.
Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title_full Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title_fullStr Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title_full_unstemmed Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title_short Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics
title_sort alpha-pet with terbium-149: evidence and perspectives for radiotheragnostics
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843804/
https://www.ncbi.nlm.nih.gov/pubmed/29564382
http://dx.doi.org/10.1186/s41181-016-0008-2
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