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Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne

BACKGROUND: Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these...

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Detalles Bibliográficos
Autores principales: Li, Shihong, Schmitz, Alexander, Lee, Hsiaoju, Mach, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843816/
https://www.ncbi.nlm.nih.gov/pubmed/29564391
http://dx.doi.org/10.1186/s41181-016-0018-0
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author Li, Shihong
Schmitz, Alexander
Lee, Hsiaoju
Mach, Robert H.
author_facet Li, Shihong
Schmitz, Alexander
Lee, Hsiaoju
Mach, Robert H.
author_sort Li, Shihong
collection PubMed
description BACKGROUND: Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six (18)F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvania using the AllinOne synthesis module. RESULTS: The development of automated syntheses with varying complexity was accomplished including HPLC purification, SPE procedures and final formulation with sterile filtration. The six radiopharmaceuticals were obtained in high yield and high specific activity with full automation on the AllinOne synthesis module under current good manufacturing practice (cGMP) guidelines. CONCLUSION: The study demonstrates the versatility of this synthesis module for the preparation of a wide variety of (18)F-labeled radiopharmaceuticals for PET imaging studies.
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spelling pubmed-58438162018-03-19 Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne Li, Shihong Schmitz, Alexander Lee, Hsiaoju Mach, Robert H. EJNMMI Radiopharm Chem Research BACKGROUND: Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six (18)F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvania using the AllinOne synthesis module. RESULTS: The development of automated syntheses with varying complexity was accomplished including HPLC purification, SPE procedures and final formulation with sterile filtration. The six radiopharmaceuticals were obtained in high yield and high specific activity with full automation on the AllinOne synthesis module under current good manufacturing practice (cGMP) guidelines. CONCLUSION: The study demonstrates the versatility of this synthesis module for the preparation of a wide variety of (18)F-labeled radiopharmaceuticals for PET imaging studies. Springer International Publishing 2016-10-10 /pmc/articles/PMC5843816/ /pubmed/29564391 http://dx.doi.org/10.1186/s41181-016-0018-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Li, Shihong
Schmitz, Alexander
Lee, Hsiaoju
Mach, Robert H.
Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title_full Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title_fullStr Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title_full_unstemmed Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title_short Automation of the Radiosynthesis of Six Different (18)F-labeled radiotracers on the AllinOne
title_sort automation of the radiosynthesis of six different (18)f-labeled radiotracers on the allinone
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843816/
https://www.ncbi.nlm.nih.gov/pubmed/29564391
http://dx.doi.org/10.1186/s41181-016-0018-0
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