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Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats

INTRODUCTION: To clarify the importance of the vascular concentration of an angiotensin II receptor blocker (ARB) to its hypotensive effect, the relationships between the drug concentrations in plasma and vascular tissues and the hypotensive effect after administration of an ARB were compared. MATER...

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Detalles Bibliográficos
Autores principales: Takai, Shinji, Sakonjo, Hiroshi, Jin, Denan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843848/
https://www.ncbi.nlm.nih.gov/pubmed/27009286
http://dx.doi.org/10.1177/1470320316633895