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Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?

Angiotensin-(3−4) (Ang-(3−4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the s...

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Autores principales: Dias, Juliana, Axelband, Flavia, Lara, Lucienne S., Muzi-Filho, Humberto, Vieyra, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843854/
https://www.ncbi.nlm.nih.gov/pubmed/28097883
http://dx.doi.org/10.1177/1470320316689338
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author Dias, Juliana
Axelband, Flavia
Lara, Lucienne S.
Muzi-Filho, Humberto
Vieyra, Adalberto
author_facet Dias, Juliana
Axelband, Flavia
Lara, Lucienne S.
Muzi-Filho, Humberto
Vieyra, Adalberto
author_sort Dias, Juliana
collection PubMed
description Angiotensin-(3−4) (Ang-(3−4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin–angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+). At the renal cell signaling level, Ang-(3−4) counteracts Ang II-type 1 receptor-mediated responses by acting as an allosteric enhancer in Ang II-type 2 receptor populations that target adenosine triphosphate-dependent Ca(2+) and Na(+) transporters through a cyclic adenosine monophosphate-activated protein kinase pathway.
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spelling pubmed-58438542018-03-20 Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system? Dias, Juliana Axelband, Flavia Lara, Lucienne S. Muzi-Filho, Humberto Vieyra, Adalberto J Renin Angiotensin Aldosterone Syst Invited Review Angiotensin-(3−4) (Ang-(3−4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin–angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+). At the renal cell signaling level, Ang-(3−4) counteracts Ang II-type 1 receptor-mediated responses by acting as an allosteric enhancer in Ang II-type 2 receptor populations that target adenosine triphosphate-dependent Ca(2+) and Na(+) transporters through a cyclic adenosine monophosphate-activated protein kinase pathway. SAGE Publications 2017-01-01 /pmc/articles/PMC5843854/ /pubmed/28097883 http://dx.doi.org/10.1177/1470320316689338 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Invited Review
Dias, Juliana
Axelband, Flavia
Lara, Lucienne S.
Muzi-Filho, Humberto
Vieyra, Adalberto
Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title_full Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title_fullStr Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title_full_unstemmed Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title_short Is angiotensin-(3–4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin–angiotensin system?
title_sort is angiotensin-(3–4) (val-tyr), the shortest angiotensin ii-derived peptide, opening new vistas on the renin–angiotensin system?
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843854/
https://www.ncbi.nlm.nih.gov/pubmed/28097883
http://dx.doi.org/10.1177/1470320316689338
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