Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner

Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell growth and survival in a cytokine screen using fluorescently labeled AML cells. RNA-sequencing...

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Detalles Bibliográficos
Autores principales: Peña-Martínez, P, Eriksson, M, Ramakrishnan, R, Chapellier, M, Högberg, C, Orsmark-Pietras, C, Richter, J, Andersson, A, Fioretos, T, Järås, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843897/
https://www.ncbi.nlm.nih.gov/pubmed/28819278
http://dx.doi.org/10.1038/leu.2017.261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843897/
https://www.ncbi.nlm.nih.gov/pubmed/28819278
http://dx.doi.org/10.1038/leu.2017.261

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