Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma

Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling. Here, we discovered the novel function of the G17V RHOA: VAV1 was identified as a G17V RHOA-specific binding...

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Detalles Bibliográficos
Autores principales: Fujisawa, M, Sakata-Yanagimoto, M, Nishizawa, S, Komori, D, Gershon, P, Kiryu, M, Tanzima, S, Fukumoto, K, Enami, T, Muratani, M, Yoshida, K, Ogawa, S, Matsue, K, Nakamura, N, Takeuchi, K, Izutsu, K, Fujimoto, K, Teshima, T, Miyoshi, H, Gaulard, P, Ohshima, K, Chiba, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843900/
https://www.ncbi.nlm.nih.gov/pubmed/28832024
http://dx.doi.org/10.1038/leu.2017.273

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