Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and normal hematopoiesis-suppressive microenviron...

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Detalles Bibliográficos
Autores principales: Kumar, B, Garcia, M, Weng, L, Jung, X, Murakami, J L, Hu, X, McDonald, T, Lin, A, Kumar, A R, DiGiusto, D L, Stein, A S, Pullarkat, V A, Hui, S K, Carlesso, N, Kuo, Y-H, Bhatia, R, Marcucci, G, Chen, C-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843902/
https://www.ncbi.nlm.nih.gov/pubmed/28816238
http://dx.doi.org/10.1038/leu.2017.259

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