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Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development

INTRODUCTION: To evaluate the influence of traditional risk factors of ischaemic heart disease and genetic factors to predict different types of acute coronary syndromes. MATERIALS AND METHODS: Five hundred and twenty-three patients with acute coronary syndromes (393 with ST elevation myocardial inf...

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Autores principales: Žaliaduonytė-Pekšienė, Diana, Lesauskaitė, Vaiva, Liutkevičienė, Rasa, Tamakauskas, Vytenis, Kviesulaitis, Vilius, Šinkūnaitė-Maršalkienė, Giedrė, Šimonytė, Sandrita, Mačiulskytė, Simonita, Tamulevičiūtė-Prascienė, Eglė, Gustienė, Olivija, Tamošiūnas, Abdonas, Žaliūnas, Remigijus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843915/
https://www.ncbi.nlm.nih.gov/pubmed/29141503
http://dx.doi.org/10.1177/1470320317739987
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author Žaliaduonytė-Pekšienė, Diana
Lesauskaitė, Vaiva
Liutkevičienė, Rasa
Tamakauskas, Vytenis
Kviesulaitis, Vilius
Šinkūnaitė-Maršalkienė, Giedrė
Šimonytė, Sandrita
Mačiulskytė, Simonita
Tamulevičiūtė-Prascienė, Eglė
Gustienė, Olivija
Tamošiūnas, Abdonas
Žaliūnas, Remigijus
author_facet Žaliaduonytė-Pekšienė, Diana
Lesauskaitė, Vaiva
Liutkevičienė, Rasa
Tamakauskas, Vytenis
Kviesulaitis, Vilius
Šinkūnaitė-Maršalkienė, Giedrė
Šimonytė, Sandrita
Mačiulskytė, Simonita
Tamulevičiūtė-Prascienė, Eglė
Gustienė, Olivija
Tamošiūnas, Abdonas
Žaliūnas, Remigijus
author_sort Žaliaduonytė-Pekšienė, Diana
collection PubMed
description INTRODUCTION: To evaluate the influence of traditional risk factors of ischaemic heart disease and genetic factors to predict different types of acute coronary syndromes. MATERIALS AND METHODS: Five hundred and twenty-three patients with acute coronary syndromes (393 with ST elevation myocardial infarction (STEMI) and 130 with non-ST elevation myocardial infarction (NSTEMI)) comprised the study group. The control group consisted of 645 subjects free from symptoms of ischaemic heart disease and stroke. Genetic polymorphisms of MMP-2 (–735) C/T, MMP-2 (–1306) C/T, MMP-3 (–1171) 5A/6A, MMP-9 (–1562) C/T and ACE I/D were evaluated using polymerase chain reaction. RESULTS: Patients with acute coronary syndromes more often had ID or II genotype than DD genotype of ACE (P = 0.04) and 5A5A or 5A6A genotype than 6A6A genotype of MMP-3 (P = 0.02) in comparison to the control group. The genotypes of other matrix metalloproteinase genes did not differ between the groups. 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. However, the polymorphism of MMP-3 5A/6A and ACE I/D was not associated with the occurrence of NSTEMI. CONCLUSIONS: Genetic polymorphisms of MMP-3 5A/6A and ACE I/D along with conventional ischaemic heart disease risk factors increase the risk of the occurrence of STEMI, while having no influence on the pathogenesis of NSTEMI.
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spelling pubmed-58439152018-03-20 Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development Žaliaduonytė-Pekšienė, Diana Lesauskaitė, Vaiva Liutkevičienė, Rasa Tamakauskas, Vytenis Kviesulaitis, Vilius Šinkūnaitė-Maršalkienė, Giedrė Šimonytė, Sandrita Mačiulskytė, Simonita Tamulevičiūtė-Prascienė, Eglė Gustienė, Olivija Tamošiūnas, Abdonas Žaliūnas, Remigijus J Renin Angiotensin Aldosterone Syst Original Article INTRODUCTION: To evaluate the influence of traditional risk factors of ischaemic heart disease and genetic factors to predict different types of acute coronary syndromes. MATERIALS AND METHODS: Five hundred and twenty-three patients with acute coronary syndromes (393 with ST elevation myocardial infarction (STEMI) and 130 with non-ST elevation myocardial infarction (NSTEMI)) comprised the study group. The control group consisted of 645 subjects free from symptoms of ischaemic heart disease and stroke. Genetic polymorphisms of MMP-2 (–735) C/T, MMP-2 (–1306) C/T, MMP-3 (–1171) 5A/6A, MMP-9 (–1562) C/T and ACE I/D were evaluated using polymerase chain reaction. RESULTS: Patients with acute coronary syndromes more often had ID or II genotype than DD genotype of ACE (P = 0.04) and 5A5A or 5A6A genotype than 6A6A genotype of MMP-3 (P = 0.02) in comparison to the control group. The genotypes of other matrix metalloproteinase genes did not differ between the groups. 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. However, the polymorphism of MMP-3 5A/6A and ACE I/D was not associated with the occurrence of NSTEMI. CONCLUSIONS: Genetic polymorphisms of MMP-3 5A/6A and ACE I/D along with conventional ischaemic heart disease risk factors increase the risk of the occurrence of STEMI, while having no influence on the pathogenesis of NSTEMI. SAGE Publications 2017-11-15 /pmc/articles/PMC5843915/ /pubmed/29141503 http://dx.doi.org/10.1177/1470320317739987 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Žaliaduonytė-Pekšienė, Diana
Lesauskaitė, Vaiva
Liutkevičienė, Rasa
Tamakauskas, Vytenis
Kviesulaitis, Vilius
Šinkūnaitė-Maršalkienė, Giedrė
Šimonytė, Sandrita
Mačiulskytė, Simonita
Tamulevičiūtė-Prascienė, Eglė
Gustienė, Olivija
Tamošiūnas, Abdonas
Žaliūnas, Remigijus
Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title_full Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title_fullStr Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title_full_unstemmed Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title_short Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development
title_sort association of the genetic and traditional risk factors of ischaemic heart disease with stemi and nstemi development
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843915/
https://www.ncbi.nlm.nih.gov/pubmed/29141503
http://dx.doi.org/10.1177/1470320317739987
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