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Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

BACKGROUND: Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD(+) biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to NAMPT inhibitors, such as FK866, can induce acquired resistance. METHODS: We...

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Detalles Bibliográficos
Autores principales:	Thongon, Natthakan, Zucal, Chiara, D’Agostino, Vito Giuseppe, Tebaldi, Toma, Ravera, Silvia, Zamporlini, Federica, Piacente, Francesco, Moschoi, Ruxanda, Raffaelli, Nadia, Quattrone, Alessandro, Nencioni, Alessio, Peyron, Jean-Francois, Provenzani, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844108/ https://www.ncbi.nlm.nih.gov/pubmed/29541451 http://dx.doi.org/10.1186/s40170-018-0174-7

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