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Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases

BACKGROUND: MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but development of drug resistance within a median progression-free survival (PFS) of 9–12 months. Understanding mechanisms of resistance and identifying effective therapeutic alternati...

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Detalles Bibliográficos
Autores principales:	Zila, Nina, Bileck, Andrea, Muqaku, Besnik, Janker, Lukas, Eichhoff, Ossia M., Cheng, Phil F., Dummer, Reinhard, Levesque, Mitchell P., Gerner, Christopher, Paulitschke, Verena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844114/ https://www.ncbi.nlm.nih.gov/pubmed/29541007 http://dx.doi.org/10.1186/s12014-018-9189-x

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