Cargando…
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
To evaluate the shared genetic etiology of type-2 diabetes (T2D) and coronary heart disease (CHD), we conducted a multi-ethnic study of genetic variation genome-wide for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D an...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224/ https://www.ncbi.nlm.nih.gov/pubmed/28869590 http://dx.doi.org/10.1038/ng.3943 |
| _version_ | 1783305217143472128 |
|---|---|
| author | Zhao, Wei Rasheed, Asif Tikkanen, Emmi Lee, Jung-Jin Butterworth, Adam S Howson, Joanna MM Assimes, Themistocles L Chowdhury, Rajiv Orho-Melander, Marju Damrauer, Scott Small, Aeron Asma, Senay Imamura, Minako Yamauch, Toshimasa Chambers, John C Chen, Peng Sapkota, Bishwa R Shah, Nabi Jabeen, Sehrish Surendran, Praveen Lu, Yingchang Zhang, Weihua Imran, Atif Abbas, Shahid Majeed, Faisal Trindade, Kevin Qamar, Nadeem Mallick, Nadeem Hayyat Yaqoob, Zia Saghir, Tahir Rizvi, Syed Nadeem Hasan Memon, Anis Rasheed, Syed Zahed Memon, Fazal-ur-Rehman Mehmood, Khalid Ahmed, Naveeduddin Qureshi, Irshad Hussain Tanveer-us-Salam, Iqbal, Wasim Malik, Uzma Mehra, Narinder Kuo, Jane Z Sheu, Wayne H-H Guo, Xiuqing Hsiung, Chao A Juang, Jyh-Ming J Taylor, Kent D Hung, Yi-Jen Lee, Wen-Jane Quertermous, Thomas Lee, I-Te Hsu, Chih-Cheng Bottinger, Erwin P. Ralhan, Sarju Teo, Yik Ying Wang, Tzung-Dau Alam, Dewan S Di Angelantonio, Emanuele Epstein, Steve Nielsen, Sune F Nordestgaard, Børge G Tybjaerg-Hansen, Anne Young, Robin Benn, Marianne Frikke-Schmidt, Ruth Kamstrup, Pia R Biobank, Michigan Jukema, J Wouter Sattar, Naveed Smit, Roelof Chung, Ren-Hua Liang, Kae-Woei Anand, Sonia Sanghera, Dharambir K Ripatti, Samuli Loos, Ruth J.F. Kooner, Jaspal S Tai, E Shyong Rotter, Jerome I Chen, Yii-Der Ida Frossard, Philippe Maeda, Shiro Kadowaki, Takashi Reilly, Muredach Pare, Guillaume Melander, Olle Salomaa, Veikko Rader, Daniel J Danesh, John Voight, Benjamin F Saleheen, Danish |
| author_facet | Zhao, Wei Rasheed, Asif Tikkanen, Emmi Lee, Jung-Jin Butterworth, Adam S Howson, Joanna MM Assimes, Themistocles L Chowdhury, Rajiv Orho-Melander, Marju Damrauer, Scott Small, Aeron Asma, Senay Imamura, Minako Yamauch, Toshimasa Chambers, John C Chen, Peng Sapkota, Bishwa R Shah, Nabi Jabeen, Sehrish Surendran, Praveen Lu, Yingchang Zhang, Weihua Imran, Atif Abbas, Shahid Majeed, Faisal Trindade, Kevin Qamar, Nadeem Mallick, Nadeem Hayyat Yaqoob, Zia Saghir, Tahir Rizvi, Syed Nadeem Hasan Memon, Anis Rasheed, Syed Zahed Memon, Fazal-ur-Rehman Mehmood, Khalid Ahmed, Naveeduddin Qureshi, Irshad Hussain Tanveer-us-Salam, Iqbal, Wasim Malik, Uzma Mehra, Narinder Kuo, Jane Z Sheu, Wayne H-H Guo, Xiuqing Hsiung, Chao A Juang, Jyh-Ming J Taylor, Kent D Hung, Yi-Jen Lee, Wen-Jane Quertermous, Thomas Lee, I-Te Hsu, Chih-Cheng Bottinger, Erwin P. Ralhan, Sarju Teo, Yik Ying Wang, Tzung-Dau Alam, Dewan S Di Angelantonio, Emanuele Epstein, Steve Nielsen, Sune F Nordestgaard, Børge G Tybjaerg-Hansen, Anne Young, Robin Benn, Marianne Frikke-Schmidt, Ruth Kamstrup, Pia R Biobank, Michigan Jukema, J Wouter Sattar, Naveed Smit, Roelof Chung, Ren-Hua Liang, Kae-Woei Anand, Sonia Sanghera, Dharambir K Ripatti, Samuli Loos, Ruth J.F. Kooner, Jaspal S Tai, E Shyong Rotter, Jerome I Chen, Yii-Der Ida Frossard, Philippe Maeda, Shiro Kadowaki, Takashi Reilly, Muredach Pare, Guillaume Melander, Olle Salomaa, Veikko Rader, Daniel J Danesh, John Voight, Benjamin F Saleheen, Danish |
| author_sort | Zhao, Wei |
| collection | PubMed |
| description | To evaluate the shared genetic etiology of type-2 diabetes (T2D) and coronary heart disease (CHD), we conducted a multi-ethnic study of genetic variation genome-wide for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and one for CHD, including a novel T2D association at a missense variant in HLA-DRB5 (OR=1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint analysis of T2D loci demonstrated that 24% are associated with CHD, highlighting eight variants - two of which are coding - where T2D and CHD associations appear to co-localize, and a novel joint T2D/CHD association which also replicated for T2D. Variants associated with both outcomes implicate several novel pathways including cellular proliferation and cardiovascular development. |
| format | Online Article Text |
| id | pubmed-5844224 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58442242018-03-10 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease Zhao, Wei Rasheed, Asif Tikkanen, Emmi Lee, Jung-Jin Butterworth, Adam S Howson, Joanna MM Assimes, Themistocles L Chowdhury, Rajiv Orho-Melander, Marju Damrauer, Scott Small, Aeron Asma, Senay Imamura, Minako Yamauch, Toshimasa Chambers, John C Chen, Peng Sapkota, Bishwa R Shah, Nabi Jabeen, Sehrish Surendran, Praveen Lu, Yingchang Zhang, Weihua Imran, Atif Abbas, Shahid Majeed, Faisal Trindade, Kevin Qamar, Nadeem Mallick, Nadeem Hayyat Yaqoob, Zia Saghir, Tahir Rizvi, Syed Nadeem Hasan Memon, Anis Rasheed, Syed Zahed Memon, Fazal-ur-Rehman Mehmood, Khalid Ahmed, Naveeduddin Qureshi, Irshad Hussain Tanveer-us-Salam, Iqbal, Wasim Malik, Uzma Mehra, Narinder Kuo, Jane Z Sheu, Wayne H-H Guo, Xiuqing Hsiung, Chao A Juang, Jyh-Ming J Taylor, Kent D Hung, Yi-Jen Lee, Wen-Jane Quertermous, Thomas Lee, I-Te Hsu, Chih-Cheng Bottinger, Erwin P. Ralhan, Sarju Teo, Yik Ying Wang, Tzung-Dau Alam, Dewan S Di Angelantonio, Emanuele Epstein, Steve Nielsen, Sune F Nordestgaard, Børge G Tybjaerg-Hansen, Anne Young, Robin Benn, Marianne Frikke-Schmidt, Ruth Kamstrup, Pia R Biobank, Michigan Jukema, J Wouter Sattar, Naveed Smit, Roelof Chung, Ren-Hua Liang, Kae-Woei Anand, Sonia Sanghera, Dharambir K Ripatti, Samuli Loos, Ruth J.F. Kooner, Jaspal S Tai, E Shyong Rotter, Jerome I Chen, Yii-Der Ida Frossard, Philippe Maeda, Shiro Kadowaki, Takashi Reilly, Muredach Pare, Guillaume Melander, Olle Salomaa, Veikko Rader, Daniel J Danesh, John Voight, Benjamin F Saleheen, Danish Nat Genet Article To evaluate the shared genetic etiology of type-2 diabetes (T2D) and coronary heart disease (CHD), we conducted a multi-ethnic study of genetic variation genome-wide for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and one for CHD, including a novel T2D association at a missense variant in HLA-DRB5 (OR=1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint analysis of T2D loci demonstrated that 24% are associated with CHD, highlighting eight variants - two of which are coding - where T2D and CHD associations appear to co-localize, and a novel joint T2D/CHD association which also replicated for T2D. Variants associated with both outcomes implicate several novel pathways including cellular proliferation and cardiovascular development. 2017-09-04 2017-10 /pmc/articles/PMC5844224/ /pubmed/28869590 http://dx.doi.org/10.1038/ng.3943 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Zhao, Wei Rasheed, Asif Tikkanen, Emmi Lee, Jung-Jin Butterworth, Adam S Howson, Joanna MM Assimes, Themistocles L Chowdhury, Rajiv Orho-Melander, Marju Damrauer, Scott Small, Aeron Asma, Senay Imamura, Minako Yamauch, Toshimasa Chambers, John C Chen, Peng Sapkota, Bishwa R Shah, Nabi Jabeen, Sehrish Surendran, Praveen Lu, Yingchang Zhang, Weihua Imran, Atif Abbas, Shahid Majeed, Faisal Trindade, Kevin Qamar, Nadeem Mallick, Nadeem Hayyat Yaqoob, Zia Saghir, Tahir Rizvi, Syed Nadeem Hasan Memon, Anis Rasheed, Syed Zahed Memon, Fazal-ur-Rehman Mehmood, Khalid Ahmed, Naveeduddin Qureshi, Irshad Hussain Tanveer-us-Salam, Iqbal, Wasim Malik, Uzma Mehra, Narinder Kuo, Jane Z Sheu, Wayne H-H Guo, Xiuqing Hsiung, Chao A Juang, Jyh-Ming J Taylor, Kent D Hung, Yi-Jen Lee, Wen-Jane Quertermous, Thomas Lee, I-Te Hsu, Chih-Cheng Bottinger, Erwin P. Ralhan, Sarju Teo, Yik Ying Wang, Tzung-Dau Alam, Dewan S Di Angelantonio, Emanuele Epstein, Steve Nielsen, Sune F Nordestgaard, Børge G Tybjaerg-Hansen, Anne Young, Robin Benn, Marianne Frikke-Schmidt, Ruth Kamstrup, Pia R Biobank, Michigan Jukema, J Wouter Sattar, Naveed Smit, Roelof Chung, Ren-Hua Liang, Kae-Woei Anand, Sonia Sanghera, Dharambir K Ripatti, Samuli Loos, Ruth J.F. Kooner, Jaspal S Tai, E Shyong Rotter, Jerome I Chen, Yii-Der Ida Frossard, Philippe Maeda, Shiro Kadowaki, Takashi Reilly, Muredach Pare, Guillaume Melander, Olle Salomaa, Veikko Rader, Daniel J Danesh, John Voight, Benjamin F Saleheen, Danish Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title_full | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title_fullStr | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title_full_unstemmed | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title_short | Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| title_sort | identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224/ https://www.ncbi.nlm.nih.gov/pubmed/28869590 http://dx.doi.org/10.1038/ng.3943 |
| work_keys_str_mv | AT zhaowei identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT rasheedasif identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT tikkanenemmi identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT leejungjin identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT butterworthadams identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT howsonjoannamm identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT assimesthemistoclesl identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT chowdhuryrajiv identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT orhomelandermarju identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT damrauerscott identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT smallaeron identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT asmasenay identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT imamuraminako identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT yamauchtoshimasa identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT chambersjohnc identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT chenpeng identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT sapkotabishwar identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT shahnabi identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT jabeensehrish identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT surendranpraveen identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT luyingchang identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT zhangweihua identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT imranatif identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT abbasshahid identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT majeedfaisal identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT trindadekevin identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT qamarnadeem identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT mallicknadeemhayyat identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT yaqoobzia identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT saghirtahir identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT rizvisyednadeemhasan identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT memonanis identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT rasheedsyedzahed identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT memonfazalurrehman identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT mehmoodkhalid identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT ahmednaveeduddin identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT qureshiirshadhussain identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT tanveerussalam identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT iqbalwasim identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT malikuzma identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT mehranarinder identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT kuojanez identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT sheuwaynehh identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT guoxiuqing identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT hsiungchaoa identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT juangjyhmingj identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT taylorkentd identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT hungyijen identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT leewenjane identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT quertermousthomas identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT leeite identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT hsuchihcheng identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT bottingererwinp identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT ralhansarju identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT teoyikying identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT wangtzungdau identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT alamdewans identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT diangelantonioemanuele identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT epsteinsteve identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT nielsensunef identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT nordestgaardbørgeg identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT tybjaerghansenanne identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT youngrobin identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT bennmarianne identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT frikkeschmidtruth identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT kamstruppiar identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT biobankmichigan identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT jukemajwouter identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT sattarnaveed identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT smitroelof identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT chungrenhua identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT liangkaewoei identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT anandsonia identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT sangheradharambirk identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT ripattisamuli identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT loosruthjf identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT koonerjaspals identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT taieshyong identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT rotterjeromei identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT chenyiiderida identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT frossardphilippe identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT maedashiro identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT kadowakitakashi identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT reillymuredach identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT pareguillaume identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT melanderolle identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT salomaaveikko identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT raderdanielj identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT daneshjohn identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT voightbenjaminf identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease AT saleheendanish identificationofnewsusceptibilitylocifortype2diabetesandsharedetiologicalpathwayswithcoronaryheartdisease |