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Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair (MMR). Ultramutated human cancers without MMR defects carry alterations in the exonuclease domain of DNA polymerase ε (Polε). They have been hy...

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Detalles Bibliográficos
Autores principales:	Barbari, Stephanie R., Kane, Daniel P., Moore, Elizabeth A., Shcherbakova, Polina V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2018
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844290/ https://www.ncbi.nlm.nih.gov/pubmed/29352080 http://dx.doi.org/10.1534/g3.118.200042

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