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The Chromatin Remodeler Isw1 Prevents CAG Repeat Expansions During Transcription in Saccharomyces cerevisiae

CAG/CTG trinucleotide repeats are unstable sequences that are difficult to replicate, repair, and transcribe due to their structure-forming nature. CAG repeats strongly position nucleosomes; however, little is known about the chromatin remodeling needed to prevent repeat instability. In a Saccharomy...

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Detalles Bibliográficos
Autores principales: Koch, Melissa R., House, Nealia C. M., Cosetta, Casey M., Jong, Robyn M., Salomon, Christelle G., Joyce, Cailin E., Philips, Elliot A., Su, Xiaofeng A., Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844344/
https://www.ncbi.nlm.nih.gov/pubmed/29305386
http://dx.doi.org/10.1534/genetics.117.300529