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Variation and covariation in strongyle infection in East African shorthorn zebu calves
Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844460/ https://www.ncbi.nlm.nih.gov/pubmed/25257652 http://dx.doi.org/10.1017/S0031182014001498 |
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author | Callaby, R. Hanotte, O. Conradie Van Wyk, I. Kiara, H. Toye, P. Mbole-Kariuki, M. N. Jennings, A. Thumbi, S. M. Coetzer, J. A. W. de. C. Bronsvoort, B. M. Knott, S. A. Woolhouse, M. E. J. Kruuk, L. E. B. |
author_facet | Callaby, R. Hanotte, O. Conradie Van Wyk, I. Kiara, H. Toye, P. Mbole-Kariuki, M. N. Jennings, A. Thumbi, S. M. Coetzer, J. A. W. de. C. Bronsvoort, B. M. Knott, S. A. Woolhouse, M. E. J. Kruuk, L. E. B. |
author_sort | Callaby, R. |
collection | PubMed |
description | Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h(2) = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h(2) = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype. |
format | Online Article Text |
id | pubmed-5844460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-58444602018-03-09 Variation and covariation in strongyle infection in East African shorthorn zebu calves Callaby, R. Hanotte, O. Conradie Van Wyk, I. Kiara, H. Toye, P. Mbole-Kariuki, M. N. Jennings, A. Thumbi, S. M. Coetzer, J. A. W. de. C. Bronsvoort, B. M. Knott, S. A. Woolhouse, M. E. J. Kruuk, L. E. B. Parasitology Article Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h(2) = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h(2) = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype. 2014-09-26 2015-03 /pmc/articles/PMC5844460/ /pubmed/25257652 http://dx.doi.org/10.1017/S0031182014001498 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Callaby, R. Hanotte, O. Conradie Van Wyk, I. Kiara, H. Toye, P. Mbole-Kariuki, M. N. Jennings, A. Thumbi, S. M. Coetzer, J. A. W. de. C. Bronsvoort, B. M. Knott, S. A. Woolhouse, M. E. J. Kruuk, L. E. B. Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title_full | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title_fullStr | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title_full_unstemmed | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title_short | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
title_sort | variation and covariation in strongyle infection in east african shorthorn zebu calves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844460/ https://www.ncbi.nlm.nih.gov/pubmed/25257652 http://dx.doi.org/10.1017/S0031182014001498 |
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