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Variation and covariation in strongyle infection in East African shorthorn zebu calves

Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort...

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Autores principales: Callaby, R., Hanotte, O., Conradie Van Wyk, I., Kiara, H., Toye, P., Mbole-Kariuki, M. N., Jennings, A., Thumbi, S. M., Coetzer, J. A. W., de. C. Bronsvoort, B. M., Knott, S. A., Woolhouse, M. E. J., Kruuk, L. E. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844460/
https://www.ncbi.nlm.nih.gov/pubmed/25257652
http://dx.doi.org/10.1017/S0031182014001498
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author Callaby, R.
Hanotte, O.
Conradie Van Wyk, I.
Kiara, H.
Toye, P.
Mbole-Kariuki, M. N.
Jennings, A.
Thumbi, S. M.
Coetzer, J. A. W.
de. C. Bronsvoort, B. M.
Knott, S. A.
Woolhouse, M. E. J.
Kruuk, L. E. B.
author_facet Callaby, R.
Hanotte, O.
Conradie Van Wyk, I.
Kiara, H.
Toye, P.
Mbole-Kariuki, M. N.
Jennings, A.
Thumbi, S. M.
Coetzer, J. A. W.
de. C. Bronsvoort, B. M.
Knott, S. A.
Woolhouse, M. E. J.
Kruuk, L. E. B.
author_sort Callaby, R.
collection PubMed
description Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h(2) = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h(2) = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype.
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spelling pubmed-58444602018-03-09 Variation and covariation in strongyle infection in East African shorthorn zebu calves Callaby, R. Hanotte, O. Conradie Van Wyk, I. Kiara, H. Toye, P. Mbole-Kariuki, M. N. Jennings, A. Thumbi, S. M. Coetzer, J. A. W. de. C. Bronsvoort, B. M. Knott, S. A. Woolhouse, M. E. J. Kruuk, L. E. B. Parasitology Article Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h(2) = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h(2) = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype. 2014-09-26 2015-03 /pmc/articles/PMC5844460/ /pubmed/25257652 http://dx.doi.org/10.1017/S0031182014001498 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Callaby, R.
Hanotte, O.
Conradie Van Wyk, I.
Kiara, H.
Toye, P.
Mbole-Kariuki, M. N.
Jennings, A.
Thumbi, S. M.
Coetzer, J. A. W.
de. C. Bronsvoort, B. M.
Knott, S. A.
Woolhouse, M. E. J.
Kruuk, L. E. B.
Variation and covariation in strongyle infection in East African shorthorn zebu calves
title Variation and covariation in strongyle infection in East African shorthorn zebu calves
title_full Variation and covariation in strongyle infection in East African shorthorn zebu calves
title_fullStr Variation and covariation in strongyle infection in East African shorthorn zebu calves
title_full_unstemmed Variation and covariation in strongyle infection in East African shorthorn zebu calves
title_short Variation and covariation in strongyle infection in East African shorthorn zebu calves
title_sort variation and covariation in strongyle infection in east african shorthorn zebu calves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844460/
https://www.ncbi.nlm.nih.gov/pubmed/25257652
http://dx.doi.org/10.1017/S0031182014001498
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