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Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy

During the last decade, our understanding of cancer cell signaling networks has significantly improved, leading to the development of various targeted therapies that have elicited profound but, unfortunately, short-lived responses. This is, in part, due to the fact that these targeted therapies igno...

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Detalles Bibliográficos
Autores principales: Kim, Eunjung, Kim, Jae-Young, Smith, Matthew A., Haura, Eric B., Anderson, Alexander R. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844524/
https://www.ncbi.nlm.nih.gov/pubmed/29522507
http://dx.doi.org/10.1371/journal.pbio.2002930