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Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy?
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed. As a result, the right ventricle (RV) is subject to an increased afterload and undergoes multiple changes, including a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844533/ https://www.ncbi.nlm.nih.gov/pubmed/29480154 http://dx.doi.org/10.1177/2045893218755979 |
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author | Loisel, Fanny Provost, Bastien Haddad, François Guihaire, Julien Amsallem, Myriam Vrtovec, Bojan Fadel, Elie Uzan, Georges Mercier, Olaf |
author_facet | Loisel, Fanny Provost, Bastien Haddad, François Guihaire, Julien Amsallem, Myriam Vrtovec, Bojan Fadel, Elie Uzan, Georges Mercier, Olaf |
author_sort | Loisel, Fanny |
collection | PubMed |
description | Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed. As a result, the right ventricle (RV) is subject to an increased afterload and undergoes multiple changes, including a decrease in capillary density. All of these dysfunctions lead to RV failure. A number of studies have shown that RV function is one of the main prognostic factors for PAH patients. Many stem cell therapies targeting the left ventricle are currently undergoing development. The promising results observed in animal models have led to clinical trials that have shown an improvement of cardiac function. In contrast to left heart disease, stem cell therapy applied to the RV has remained poorly studied, even though it too may provide a therapeutic benefit. In this review, we discuss stem cell therapy as a treatment for RV failure in PAH. We provide an overview of the results of preclinical and clinical studies for RV cell therapies. Although a large number of studies have targeted the pulmonary circulation rather than the RV directly, there are nonetheless encouraging results in the literature that indicate that cell therapies may have a direct beneficial effect on RV function. This cell therapy strategy may therefore hold great promise and warrants further studies in PAH patients. |
format | Online Article Text |
id | pubmed-5844533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58445332018-03-13 Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? Loisel, Fanny Provost, Bastien Haddad, François Guihaire, Julien Amsallem, Myriam Vrtovec, Bojan Fadel, Elie Uzan, Georges Mercier, Olaf Pulm Circ Review Article Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed. As a result, the right ventricle (RV) is subject to an increased afterload and undergoes multiple changes, including a decrease in capillary density. All of these dysfunctions lead to RV failure. A number of studies have shown that RV function is one of the main prognostic factors for PAH patients. Many stem cell therapies targeting the left ventricle are currently undergoing development. The promising results observed in animal models have led to clinical trials that have shown an improvement of cardiac function. In contrast to left heart disease, stem cell therapy applied to the RV has remained poorly studied, even though it too may provide a therapeutic benefit. In this review, we discuss stem cell therapy as a treatment for RV failure in PAH. We provide an overview of the results of preclinical and clinical studies for RV cell therapies. Although a large number of studies have targeted the pulmonary circulation rather than the RV directly, there are nonetheless encouraging results in the literature that indicate that cell therapies may have a direct beneficial effect on RV function. This cell therapy strategy may therefore hold great promise and warrants further studies in PAH patients. SAGE Publications 2018-02-26 /pmc/articles/PMC5844533/ /pubmed/29480154 http://dx.doi.org/10.1177/2045893218755979 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ Creative Commons CC-BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Loisel, Fanny Provost, Bastien Haddad, François Guihaire, Julien Amsallem, Myriam Vrtovec, Bojan Fadel, Elie Uzan, Georges Mercier, Olaf Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title | Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title_full | Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title_fullStr | Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title_full_unstemmed | Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title_short | Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
title_sort | stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844533/ https://www.ncbi.nlm.nih.gov/pubmed/29480154 http://dx.doi.org/10.1177/2045893218755979 |
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