Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and also an important metabolic disorder associated with insulin resistance (IR). Hyperandrogenism is a key feature of PCOS. However, whether hyperandrogenism can cause IR in PCOS remains largely unknown....

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Detalles Bibliográficos
Autores principales: Song, Xi, Shen, Qiyang, Fan, Liting, Yu, Qiuxiao, Jia, Xiao, Sun, Yu, Bai, Wenpei, Kang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844717/
https://www.ncbi.nlm.nih.gov/pubmed/29552281
http://dx.doi.org/10.18632/oncotarget.24190

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