Cargando…

Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors

Children with high risk sarcoma have a poor prognosis despite surgical resection, irradiation and chemotherapy. Alternative therapies are urgently needed. Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are surface proteins expressed by some pediatric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pilbeam, Kristy, Wang, Hongbo, Taras, Elizabeth, Bergerson, Rachel J., Ettestad, Brianna, DeFor, Todd, Borgatti, Antonella, Vallera, Daniel A., Verneris, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844719/ https://www.ncbi.nlm.nih.gov/pubmed/29552283 http://dx.doi.org/10.18632/oncotarget.21187

Ejemplares similares

Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin
por: Oh, Felix, et al.
Publicado: (2018)

Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors
por: Oh, Felix, et al.
Publicado: (2020)

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies
por: Schmohl, Joerg U., et al.
Publicado: (2018)

Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity
por: Vallera, Daniel A., et al.
Publicado: (2018)

Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
por: Wang, Haoyu, et al.
Publicado: (2020)

Hemangiosarcoma and its cancer stem cell sub-population are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors
por: Schappa, Jill T, et al.
Publicado: (2013)

Clinical targeting recombinant immunotoxins for cancer therapy
por: Li, Meng, et al.
Publicado: (2017)

Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors
por: Hagerty, Brendan L., et al.
Publicado: (2020)

Immunotoxins: The Role of the Toxin (†)
por: Antignani, Antonella, et al.
Publicado: (2013)

Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
por: Olsen, Cathrine Elisabeth, et al.
Publicado: (2019)

A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas
por: Zhang, Yonghong, et al.
Publicado: (2015)

CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model
por: Wang, Zhaohui, et al.
Publicado: (2023)

Novel EGFR-bispecific recombinant immunotoxin based on cucurmosin shows potent anti-tumor efficiency in vitro
por: Zhang, Caiyun, et al.
Publicado: (2021)

Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway
por: Gadadhar, Sudarshan, et al.
Publicado: (2013)

Naptumomab Estafenatox: Targeted Immunotherapy with a Novel Immunotoxin
por: Eisen, Tim, et al.
Publicado: (2014)

Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer
por: Fleming, Bryan D., et al.
Publicado: (2016)

Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers
por: Simon, Nathan, et al.
Publicado: (2016)

A Novel Bispecific Immunotoxin Delivered by Human Bone Marrow-Derived Mesenchymal Stem Cells to Target Blood Vessels and Vasculogenic Mimicry of Malignant Gliomas [Retraction]
Publicado: (2021)

Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Tumor Microenvironment
por: Koo, Jane, et al.
Publicado: (2020)

Targeting malignant B cells with an immunotoxin against ROR1
por: Baskar, Sivasubramanian, et al.
Publicado: (2012)

Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties
por: Kawakami, Koji, et al.
Publicado: (2006)

In vivo solid tumor targeting with recombinant VEGF-diphtheria immunotoxin
por: Hosseininejad-Chafi, Mohammad, et al.
Publicado: (2022)

Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment
por: Narbona, Javier, et al.
Publicado: (2023)

Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM
por: Lv, Minghua, et al.
Publicado: (2015)

Towards Engineering Novel PE-Based Immunotoxins by Targeting Them to the Nucleus
por: Borowiec, Marta, et al.
Publicado: (2016)

Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update
por: Fleming, Bryan D., et al.
Publicado: (2020)

Recombinant immunotoxins development for HER2-based targeted cancer therapies
por: Mahmoudi, Reza, et al.
Publicado: (2021)

Urokinase receptor and resistance to targeted anticancer agents
por: Gonias, Steven L., et al.
Publicado: (2015)

A tri-specific killer engager against mesothelin targets NK cells towards lung cancer
por: Kennedy, Philippa R., et al.
Publicado: (2023)

Bispecific protein targets prostate cancer
por: Burgess, Antony W.
Publicado: (2017)

B7-1 (CD80) as target for immunotoxin therapy for Hodgkin's disease.
por: Vooijs, W. C., et al.
Publicado: (1997)

Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells
por: Spiess, Katja, et al.
Publicado: (2017)

Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers
por: Fuchs, Hendrik, et al.
Publicado: (2016)

Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective
por: Li, Mengyu, et al.
Publicado: (2022)

NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo
por: Vallera, Daniel A., et al.
Publicado: (2020)

Immunotoxins: experimental design
por: Dall, P, et al.
Publicado: (2001)

Countering immunotoxin immunogenicity
por: Flavell, David J
Publicado: (2016)

Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
por: Carriero, Maria Vincenza, et al.
Publicado: (2017)

Therapeutic Strategies Targeting Urokinase and Its Receptor in Cancer
por: Masucci, Maria Teresa, et al.
Publicado: (2022)

Solid-Phase Bioconjugation of Heterobifunctional Adaptors for Versatile Assembly of Bispecific Targeting Ligands
por: Liu, Hong Yan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tptocsflr5o5gemkjs7nf82h3i