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Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C
We investigated the long-term risk of hepatocellular carcinoma (HCC) in dual-infected hepatitis B and C patients after eradication of hepatitis C virus (HCV). A total of 164 (62% male, median age, 50.5 years) hepatitis B and C dual-infected patients who achieved HCV sustained virological response we...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844742/ https://www.ncbi.nlm.nih.gov/pubmed/29552306 http://dx.doi.org/10.18632/oncotarget.24219 |
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author | Yeh, Ming-Lun Huang, Ching-I Huang, Chung-Feng Hsieh, Meng-Hsuan Hsieh, Ming-Yen Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Kuo, Po-Lin Kuo, Hsing-Tao Dai, Chia-Yen Yu, Ming-Lung Chuang, Wan-Long |
author_facet | Yeh, Ming-Lun Huang, Ching-I Huang, Chung-Feng Hsieh, Meng-Hsuan Hsieh, Ming-Yen Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Kuo, Po-Lin Kuo, Hsing-Tao Dai, Chia-Yen Yu, Ming-Lung Chuang, Wan-Long |
author_sort | Yeh, Ming-Lun |
collection | PubMed |
description | We investigated the long-term risk of hepatocellular carcinoma (HCC) in dual-infected hepatitis B and C patients after eradication of hepatitis C virus (HCV). A total of 164 (62% male, median age, 50.5 years) hepatitis B and C dual-infected patients who achieved HCV sustained virological response were recruited. Half the patients were HCV genotype 1 with a median viral load of 5.5 log10 IU/mL, and 22.6%had an HBV DNA level ≥ 2000 IU/mL before therapy. HCC developed in 14 patients (8.5%), with an annual incidence of 1.38% per person-year. The 3-year, 5-year, 10-year, and 15-year cumulative probabilities were 2.5%, 5.1%, 12.6%, and 22.7%, respectively. Six months after treatment, a Cox regression hazard analysis revealed platelet level (HR: 0.98, 95% CI: 0.957–0.999, P = 0.038) and AFP level (HR: 1.20, 95% CI: 1.031–1.400, P = 0.019) to be independent factors in HCC. A higher 10-year cumulative risk of HCC was detected in patients with 6-month post-treatment AFP levels > 5.0 ng/mL and platelet levels < 130 x1000/µL (54.9%), compared to patients with neither (8.6%). Although the risk of HCC is low, surveillance of HCC is encouraged in dual-infected patients after eradication of HCV. Post-treatment AFP and platelet levels predict HCC development. |
format | Online Article Text |
id | pubmed-5844742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58447422018-03-16 Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C Yeh, Ming-Lun Huang, Ching-I Huang, Chung-Feng Hsieh, Meng-Hsuan Hsieh, Ming-Yen Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Kuo, Po-Lin Kuo, Hsing-Tao Dai, Chia-Yen Yu, Ming-Lung Chuang, Wan-Long Oncotarget Research Paper We investigated the long-term risk of hepatocellular carcinoma (HCC) in dual-infected hepatitis B and C patients after eradication of hepatitis C virus (HCV). A total of 164 (62% male, median age, 50.5 years) hepatitis B and C dual-infected patients who achieved HCV sustained virological response were recruited. Half the patients were HCV genotype 1 with a median viral load of 5.5 log10 IU/mL, and 22.6%had an HBV DNA level ≥ 2000 IU/mL before therapy. HCC developed in 14 patients (8.5%), with an annual incidence of 1.38% per person-year. The 3-year, 5-year, 10-year, and 15-year cumulative probabilities were 2.5%, 5.1%, 12.6%, and 22.7%, respectively. Six months after treatment, a Cox regression hazard analysis revealed platelet level (HR: 0.98, 95% CI: 0.957–0.999, P = 0.038) and AFP level (HR: 1.20, 95% CI: 1.031–1.400, P = 0.019) to be independent factors in HCC. A higher 10-year cumulative risk of HCC was detected in patients with 6-month post-treatment AFP levels > 5.0 ng/mL and platelet levels < 130 x1000/µL (54.9%), compared to patients with neither (8.6%). Although the risk of HCC is low, surveillance of HCC is encouraged in dual-infected patients after eradication of HCV. Post-treatment AFP and platelet levels predict HCC development. Impact Journals LLC 2018-01-13 /pmc/articles/PMC5844742/ /pubmed/29552306 http://dx.doi.org/10.18632/oncotarget.24219 Text en Copyright: © 2018 Yeh et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yeh, Ming-Lun Huang, Ching-I Huang, Chung-Feng Hsieh, Meng-Hsuan Hsieh, Ming-Yen Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Kuo, Po-Lin Kuo, Hsing-Tao Dai, Chia-Yen Yu, Ming-Lung Chuang, Wan-Long Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title | Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title_full | Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title_fullStr | Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title_full_unstemmed | Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title_short | Post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis B and C patients after eradication of hepatitis C |
title_sort | post-treatment alpha fetoprotein and platelets predict hepatocellular carcinoma development in dual-infected hepatitis b and c patients after eradication of hepatitis c |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844742/ https://www.ncbi.nlm.nih.gov/pubmed/29552306 http://dx.doi.org/10.18632/oncotarget.24219 |
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