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Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis
Previous studies have suggested that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of developing cervical cancer. However, the published results on this subject matter are controversial. The aim of this study was to conduct a meta-analysis of published reports to more...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844753/ https://www.ncbi.nlm.nih.gov/pubmed/29552317 http://dx.doi.org/10.18632/oncotarget.24193 |
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author | Guo, Chong Wen, Li Song, Ju-Kun Zeng, Weng-Jing Dan, Chao Niu, Yu-Ming Shen, Ming |
author_facet | Guo, Chong Wen, Li Song, Ju-Kun Zeng, Weng-Jing Dan, Chao Niu, Yu-Ming Shen, Ming |
author_sort | Guo, Chong |
collection | PubMed |
description | Previous studies have suggested that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of developing cervical cancer. However, the published results on this subject matter are controversial. The aim of this study was to conduct a meta-analysis of published reports to more precisely investigate the relationship between IL-10 polymorphisms and cervical cancer risk. Five online databases (PubMed, Embase, Web of SCI, CNKI and Wanfang) were searched, and seventeen articles with sufficient quantitative information were included in our meta-analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between IL-10 polymorphisms and cervical cancer risk. Publication bias, sensitivity and cumulative analyses were also performed to support our findings. Overall, there was a significant association between the IL-10 -1082A > G polymorphism and cervical cancer risk observed in the total population (G vs. A: OR = 1.60, 95% CI = 1.12–2.29, P = 0.01, I(2) = 92.3%; AG vs. AA: OR = 1.34, 95% CI = 1.04-1.74, P = 0.03, I(2) = 65.9%; AG + GG vs. AA: OR = 1.58, 95% CI = 1.11–2.25, P = 0.01, I(2) = 84.4%), and the same results were obtained in the subgroup analysis. Moreover, the IL-10 -819 T > C polymorphism exhibited a significant, protective effect against cervical cancer. In summary, our meta-analysis suggests that IL-10 polymorphisms may play a variety of roles in regard to cervical cancer risk, especially in Asians. |
format | Online Article Text |
id | pubmed-5844753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58447532018-03-16 Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis Guo, Chong Wen, Li Song, Ju-Kun Zeng, Weng-Jing Dan, Chao Niu, Yu-Ming Shen, Ming Oncotarget Meta-Analysis Previous studies have suggested that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of developing cervical cancer. However, the published results on this subject matter are controversial. The aim of this study was to conduct a meta-analysis of published reports to more precisely investigate the relationship between IL-10 polymorphisms and cervical cancer risk. Five online databases (PubMed, Embase, Web of SCI, CNKI and Wanfang) were searched, and seventeen articles with sufficient quantitative information were included in our meta-analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between IL-10 polymorphisms and cervical cancer risk. Publication bias, sensitivity and cumulative analyses were also performed to support our findings. Overall, there was a significant association between the IL-10 -1082A > G polymorphism and cervical cancer risk observed in the total population (G vs. A: OR = 1.60, 95% CI = 1.12–2.29, P = 0.01, I(2) = 92.3%; AG vs. AA: OR = 1.34, 95% CI = 1.04-1.74, P = 0.03, I(2) = 65.9%; AG + GG vs. AA: OR = 1.58, 95% CI = 1.11–2.25, P = 0.01, I(2) = 84.4%), and the same results were obtained in the subgroup analysis. Moreover, the IL-10 -819 T > C polymorphism exhibited a significant, protective effect against cervical cancer. In summary, our meta-analysis suggests that IL-10 polymorphisms may play a variety of roles in regard to cervical cancer risk, especially in Asians. Impact Journals LLC 2018-01-12 /pmc/articles/PMC5844753/ /pubmed/29552317 http://dx.doi.org/10.18632/oncotarget.24193 Text en Copyright: © 2018 Guo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Guo, Chong Wen, Li Song, Ju-Kun Zeng, Weng-Jing Dan, Chao Niu, Yu-Ming Shen, Ming Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title | Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title_full | Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title_fullStr | Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title_full_unstemmed | Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title_short | Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
title_sort | significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844753/ https://www.ncbi.nlm.nih.gov/pubmed/29552317 http://dx.doi.org/10.18632/oncotarget.24193 |
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