Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1

Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that promote cancer cell invasive growth and metastasis, yet the mechanisms mediating these functions still largely remain elusive. We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhanc...

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Detalles Bibliográficos
Autores principales: Tanaka, Noriaki, Zhao, Mei, Tang, Lin, Patel, Ameeta A., Xi, Qing, Van, Hieu T., Takahashi, Hideaki, Osman, Abdullah A., Zhang, Jiexin, Wang, Jing, Myers, Jeffrey N., Zhou, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844800/
https://www.ncbi.nlm.nih.gov/pubmed/29269868
http://dx.doi.org/10.1038/s41388-017-0032-z

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