MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early pha...

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Detalles Bibliográficos
Autores principales: Tripathi, Vivek, Agarwal, Himanshi, Priya, Swati, Batra, Harish, Modi, Priyanka, Pandey, Monica, Saha, Dhurjhoti, Raghavan, Sathees C., Sengupta, Sagar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844875/
https://www.ncbi.nlm.nih.gov/pubmed/29523790
http://dx.doi.org/10.1038/s41467-018-03393-8

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