Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a nuclear and mitochondrial protein that in nuclei and in vitro repairs blocked 3′ DNA termini such as 3′ phosphotyrosine conjugates resulting from stalling of topoisomerase I-DNA intermediates. Its mutation also causes spinocerebellar ataxia with axonal neu...

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Detalles Bibliográficos
Autores principales: Fam, Hok Khim, Choi, Kunho, Fougner, Lauren, Lim, Chinten James, Boerkoel, Cornelius F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844879/
https://www.ncbi.nlm.nih.gov/pubmed/29523818
http://dx.doi.org/10.1038/s41598-018-22547-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844879/
https://www.ncbi.nlm.nih.gov/pubmed/29523818
http://dx.doi.org/10.1038/s41598-018-22547-8

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