Cargando…

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under pathological circumstances, senescence can adversely affect organ function, viability and regeneration. We have developed a mouse model of biliary sen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferreira-Gonzalez, Sofia, Lu, Wei-Yu, Raven, Alexander, Dwyer, Benjamin, Man, Tak Yung, O’Duibhir, Eoghan, Lewis, Philip J. Starkey, Campana, Lara, Kendall, Tim J., Bird, Thomas G., Tarrats, Nuria, Acosta, Juan-Carlos, Boulter, Luke, Forbes, Stuart J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844882/ https://www.ncbi.nlm.nih.gov/pubmed/29523787 http://dx.doi.org/10.1038/s41467-018-03299-5

Ejemplares similares

Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration
por: Raven, Alexander, et al.
Publicado: (2017)

Alternatively activated macrophages promote resolution of necrosis following acute liver injury
por: Starkey Lewis, Philip, et al.
Publicado: (2020)

Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening
por: O'Duibhir, Eoghan, et al.
Publicado: (2016)

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
por: Hallett, John M., et al.
Publicado: (2022)

Author Correction: Injection of embryonic stem cell-derived macrophages ameliorates fibrosis in a murine model of liver injury
por: Haideri, Sharmin S., et al.
Publicado: (2017)

Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
por: Haideri, Sharmin S., et al.
Publicado: (2017)

Hepatic progenitor cells of biliary origin with liver repopulation capacity
por: Lu, Wei-Yu, et al.
Publicado: (2015)

Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters
por: de Jonge, Wim J, et al.
Publicado: (2016)

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
por: Hari, Priya, et al.
Publicado: (2019)

A complex secretory program orchestrated by the inflammasome controls paracrine senescence
por: Acosta, Juan Carlos, et al.
Publicado: (2013)

Paracrine roles of cellular senescence in promoting tumourigenesis
por: Gonzalez-Meljem, Jose Mario, et al.
Publicado: (2018)

Notch Signaling Mediates Secondary Senescence
por: Teo, Yee Voan, et al.
Publicado: (2019)

Pmch-Deficiency in Rats Is Associated with Normal Adipocyte Differentiation and Lower Sympathetic Adipose Drive
por: Mul, Joram D., et al.
Publicado: (2013)

Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II
por: Meinel, Dominik M., et al.
Publicado: (2013)

Cell cycle population effects in perturbation studies
por: O'Duibhir, Eoghan, et al.
Publicado: (2014)

Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence
por: Pantazi, Asimina, et al.
Publicado: (2019)

Senescence and senotherapies in biliary atresia and biliary cirrhosis
por: Jannone, Giulia, et al.
Publicado: (2023)

Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
por: Guest, R. V., et al.
Publicado: (2017)

Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis
por: Gonzalez-Meljem, Jose Mario, et al.
Publicado: (2021)

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
por: Lagnado, Anthony, et al.
Publicado: (2021)

Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma
por: Hou, Jingang, et al.
Publicado: (2017)

Biliary Epithelial Apoptosis, Autophagy, and Senescence in Primary Biliary Cirrhosis
por: Sasaki, Motoko, et al.
Publicado: (2010)

GPCRs in Autocrine and Paracrine Regulations
por: Tse, Lap Hang, et al.
Publicado: (2019)

Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection
por: Brain, J G, et al.
Publicado: (2013)

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response
por: Tsuji, Shunya, et al.
Publicado: (2022)

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells
por: Elsayed, Ranya, et al.
Publicado: (2021)

Influenza Virus-Induced Paracrine Cellular Senescence of the Lung Contributes to Enhanced Viral Load
por: Schulz, Luise, et al.
Publicado: (2023)

Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance
por: Wu, Qiwei, et al.
Publicado: (2022)

Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells
por: Lyall, Marcus J., et al.
Publicado: (2018)

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
por: Fernández-Duran, Irene, et al.
Publicado: (2021)

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP
por: Meadows, Vik, et al.
Publicado: (2021)

Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung
por: Lugo, Roberto, et al.
Publicado: (2016)

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB Pathway
por: Chou, Lun-Yin, et al.
Publicado: (2022)

Protocol for quantitative evaluation of the impact of paracrine senescence on cellular reprogramming in cultured cells and mouse models
por: Chantrel, Jérémy, et al.
Publicado: (2023)

Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development
por: Malaise, Olivier, et al.
Publicado: (2019)

SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells
por: Meyer, Keith, et al.
Publicado: (2021)

MicroRNA therapy confers anti-senescent effects on doxorubicin-related cardiotoxicity by intracellular and paracrine signaling
por: Xia, Wenzheng, et al.
Publicado: (2021)

Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response
por: Kan, Anne A., et al.
Publicado: (2012)

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
por: Wilson, D. H., et al.
Publicado: (2020)

Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis
por: Malaquin, Nicolas, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_036pvn9m0046frjnntvg95bq0m