SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In this study, SLIT2 and ROBO1 were upregulated in OS, and higher expression of ROBO1 was associa...

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Detalles Bibliográficos
Autores principales: Zhao, Shu-Jie, Shen, Yi-Fei, Li, Qing, He, Yun-Jie, Zhang, Yun-Kun, Hu, Li-Peng, Jiang, Yu-Qing, Xu, Nan-Wei, Wang, Yu-Ji, Li, Jun, Wang, Ya-Hui, Liu, Fei, Zhang, Rong, Yin, Guo-Yong, Tang, Jin-Hai, Zhou, Dong, Zhang, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844886/
https://www.ncbi.nlm.nih.gov/pubmed/29523788
http://dx.doi.org/10.1038/s41419-018-0419-y

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