Complementarity of assembly-first and mapping-first approaches for alternative splicing annotation and differential analysis from RNAseq data

Genome-wide analyses estimate that more than 90% of multi exonic human genes produce at least two transcripts through alternative splicing (AS). Various bioinformatics methods are available to analyze AS from RNAseq data. Most methods start by mapping the reads to an annotated reference genome, but...

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Detalles Bibliográficos
Autores principales: Benoit-Pilven, Clara, Marchet, Camille, Chautard, Emilie, Lima, Leandro, Lambert, Marie-Pierre, Sacomoto, Gustavo, Rey, Amandine, Cologne, Audric, Terrone, Sophie, Dulaurier, Louis, Claude, Jean-Baptiste, Bourgeois, Cyril F., Auboeuf, Didier, Lacroix, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844962/
https://www.ncbi.nlm.nih.gov/pubmed/29523794
http://dx.doi.org/10.1038/s41598-018-21770-7

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