A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

Proteins are an increasingly important class of drugs used as therapeutic as well as diagnostic agents. A generic physiologically based pharmacokinetic (PBPK) model was developed in order to represent at whole body level the fundamental mechanisms driving the distribution and clearance of large mole...

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Detalles Bibliográficos
Autores principales: Niederalt, Christoph, Kuepfer, Lars, Solodenko, Juri, Eissing, Thomas, Siegmund, Hans-Ulrich, Block, Michael, Willmann, Stefan, Lippert, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845054/
https://www.ncbi.nlm.nih.gov/pubmed/29234936
http://dx.doi.org/10.1007/s10928-017-9559-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845054/
https://www.ncbi.nlm.nih.gov/pubmed/29234936
http://dx.doi.org/10.1007/s10928-017-9559-4

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