Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington’s disease

The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a multifunctional neuronal calcium sensor (NCS) that controls Ca(2+) and protein homeostasis through gene regulation and protein-protein interactions. Downregulation of DREAM is part of an endogenous neuropro...

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Detalles Bibliográficos
Autores principales: López-Hurtado, Alejandro, Burgos, Daniel F., González, Paz, Dopazo, Xose M., González, Valentina, Rábano, Alberto, Mellström, Britt, Naranjo, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845147/
https://www.ncbi.nlm.nih.gov/pubmed/29523177
http://dx.doi.org/10.1186/s13041-018-0359-6

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